时间导航:从空间导航角度看大脑如何编码时间。

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-01-21 DOI:10.1146/annurev-neuro-101419-011117
John B Issa, Gilad Tocker, Michael E Hasselmo, James G Heys, Daniel A Dombeck
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引用次数: 0

摘要

与毫秒计时和昼夜节律相比,以秒到分钟为时间尺度的间隔计时分布在多个脑区,可能使用不同的电路机制。然而,对它的研究却很困难,因为这种时间尺度的计时与其他行为纠缠不清。有几种电路和细胞机制可以产生携带定时信息的顺序或斜坡活动模式。在此,我们建议一种有效的方法是将时间间隔计时与空间导航相提并论,这样就可以在感兴趣的变量和必要的数学运算之间建立直接的类比关系。除了设计实验将计时行为从其他变量中分离或分辨出来之外,新技术还将促进研究,直接解决导致时间间隔计时的神经机制问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Navigating Through Time: A Spatial Navigation Perspective on How the Brain May Encode Time.

Interval timing, which operates on timescales of seconds to minutes, is distributed across multiple brain regions and may use distinct circuit mechanisms as compared to millisecond timing and circadian rhythms. However, its study has proven difficult, as timing on this scale is deeply entangled with other behaviors. Several circuit and cellular mechanisms could generate sequential or ramping activity patterns that carry timing information. Here we propose that a productive approach is to draw parallels between interval timing and spatial navigation, where direct analogies can be made between the variables of interest and the mathematical operations necessitated. Along with designing experiments that isolate or disambiguate timing behavior from other variables, new techniques will facilitate studies that directly address the neural mechanisms that are responsible for interval timing.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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