青海高原红狐PRNP基因的克隆与分析。

IF 1.9 3区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prion Pub Date : 2020-12-01 DOI:10.1080/19336896.2019.1704496

Xue-Hua Yang, Kang Xiao, Yuezhang Wu, Liping Gao, Dongdong Chen, Xiao-Ping Dong, Qi Shi

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引用次数: 1

摘要

PRNP基因编码PrP蛋白，该蛋白在不同物种间具有保守性，与朊病毒疾病的易感性有关。本研究克隆了青海高原狐猴(Vulpes corsac)的PRNP全长基因，并对其进行了测序。Vulpes corsac PrP与其他3种狐的氨基酸序列同源性为100%。并分析了Vulpes corsac PrP与人、犬、牛、鹿、羊、羊、骆驼、猫、鼠、鼠、仓鼠等动物的类群关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

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Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those of the other three species of foxes. The taxa relationship of Vulpes corsac PrP with other species of animals, including human, canine, bovine, cervus, capra, ovis, camelus, felis, Mustela, mouse and hamster were also analysed.

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来源期刊

Prion 生物-生化与分子生物学

CiteScore

5.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Prion is the first international peer-reviewed open access journal to focus exclusively on protein folding and misfolding, protein assembly disorders, protein-based and structural inheritance. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The overriding criteria for publication in Prion are originality, scientific merit and general interest.