青海高原红狐PRNP基因的克隆与分析。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-12-01 DOI:10.1080/19336896.2019.1704496

Xue-Hua Yang, Kang Xiao, Yuezhang Wu, Liping Gao, Dongdong Chen, Xiao-Ping Dong, Qi Shi

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引用次数: 1

摘要

PRNP基因编码PrP蛋白，该蛋白在不同物种间具有保守性，与朊病毒疾病的易感性有关。本研究克隆了青海高原狐猴(Vulpes corsac)的PRNP全长基因，并对其进行了测序。Vulpes corsac PrP与其他3种狐的氨基酸序列同源性为100%。并分析了Vulpes corsac PrP与人、犬、牛、鹿、羊、羊、骆驼、猫、鼠、鼠、仓鼠等动物的类群关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

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Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those of the other three species of foxes. The taxa relationship of Vulpes corsac PrP with other species of animals, including human, canine, bovine, cervus, capra, ovis, camelus, felis, Mustela, mouse and hamster were also analysed.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.