爱尔兰塞特犬麸质敏感性肠病与人类乳糜泻的相似之处。

Federico Biagi, Stiliano Maimaris, Carla G Vecchiato, Martina Costetti, Giacomo Biagi
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引用次数: 1

摘要

爱尔兰塞特犬的麸质敏感性肠病是一种免疫介导的麸质不耐受,麸质是小麦、大麦、黑麦和燕麦中发现的蛋白质,让人想起人类的乳糜泻。肠道组织学病变包括部分绒毛萎缩,淋巴细胞和浆细胞浸润固有层,上皮内淋巴细胞计数增加。麸质敏感性肠病是通过常染色体隐性遗传传播的,其发病机制似乎涉及细胞介导的免疫,而不是体液免疫。与健康的狗相比,患病的爱尔兰塞特犬的抗麦胶蛋白抗体水平较低,尽管这一发现的意义尚不清楚。爱尔兰塞特犬受麸质敏感性肠病影响,表现为慢性间歇性腹泻和体重减轻。无麸质饮食的使用对于疾病的诊断和治疗都是必不可少的。在这篇综述中,我们讨论了爱尔兰塞特犬麸质敏感性肠病与人类乳糜泻之间的相似之处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gluten-sensitive enteropathy of the Irish Setter and similarities with human celiac disease.

Gluten-sensitive enteropathy of the Irish Setter is an immune-mediated intolerance to gluten, the protein found in wheat, barley, rye, and oats, reminiscent of human celiac disease. Intestinal histological lesions include partial villous atrophy, infiltration of the lamina propria by lymphocytes and plasma cells, and an increased intraepithelial lymphocyte count. Gluten-sensitive enteropathy is transmitted via autosomal recessive inheritance and its pathogenesis appears to involve cell-mediated immunity but not humoral immunity. In comparison to healthy dogs, levels of antigliadin antibodies in diseased Irish Setters are lower, although the significance of this finding is unclear. Irish Setters affected by gluten-sensitive enteropathy present with chronic intermittent diarrhea and weight loss. The use of a gluten-free diet is indispensable both for diagnosis of the disease and for therapy. In this review we discuss the similarities between gluten-sensitive enteropathy of the Irish Setter and human celiac disease.

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