在联合培养中，模拟过氧化氢酶的金纳米颗粒抑制了气态乳杆菌对食源性肠道病原体的拮抗作用。

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2019-01-01 Epub Date: 2019-04-24 DOI:10.1080/10590501.2019.1591698

Suqin Zhu, Mingyong Zeng, Wei Guo, Guangxin Feng, Haohao Wu

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引用次数: 2

摘要

金纳米颗粒(AuNPs)在小鼠结肠炎期间诱导肠道生态失调，但其潜在机制尚不清楚。在这里，我们评估了AuNPs(直径5 nm，包被单宁酸、聚乙烯吡咯烷酮或柠檬酸盐)在好氧培养条件下对产气乳杆菌肠道菌株H2O2积累和病原体拮抗的影响。AuNPs (0.65 μg/mL)降低了L. gasseri 50%以上的H2O2积累，显著抑制了L. gasseri对4种食源性肠道致病菌(血清型肠炎沙门氏菌、鼠伤寒沙门氏菌、大肠杆菌、单核增生李斯特菌和金黄色葡萄球菌)生长的拮抗作用。

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Catalase-mimetic gold nanoparticles inhibit the antagonistic action of Lactobacillus gasseri toward foodborne enteric pathogens in associative cultures.

Gold nanoparticles (AuNPs) have been previously shown to induce gut dysbiosis during colitis in mice, but the underlying mechanism is not clear yet. Here, we evaluated the effects of AuNPs (5 nm diameter, coated with tannic acid, polyvinylpyrrolidone or citrate) on H₂O₂ accumulation and pathogen antagonization by an intestinal strain of Lactobacillus gasseri under aerobic cultural conditions. AuNPs (0.65 μg/mL) reduced over 50% of H₂O₂ accumulation by L. gasseri, and significantly inhibited the antagonistic action of L. gasseri on growth of four foodborne enteric pathogens, i.e. Salmonella enterica serovar Typhimurium, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus in associative cultures.

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来源期刊

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews 环境科学-毒理学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.