Wnt抑制因子1(一种控制Wnt和hedgehog通路的分泌蛋白)的结构、功能和疾病相关性

IF 1.8 4区生物学 Q4 CELL BIOLOGY

Growth factors Pub Date : 2019-04-01 Epub Date: 2019-06-18 DOI:10.1080/08977194.2019.1626380

Krisztina Kerekes, László Bányai, Mária Trexler, László Patthy

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引用次数: 13

摘要

wnt和刺猬(Hh)是大的、脂质修饰的细胞外形态因子，在后生动物的胚胎发育和干细胞增殖中起关键作用。这两种形态因子都通过g蛋白偶联受体家族的七螺旋卷曲型受体发出信号，还有其他一些相似之处表明Hh和Wnt途径具有共同的进化起源。有证据表明，分泌蛋白Wnt抑制因子1 (WIF1)调节Wnt和Hhs的活性，从而可能促进这些途径的交织。在本文中，我们综述了WIF1的结构、进化、分子相互作用和功能，重点介绍了它在致癌中的作用。

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Structure, function and disease relevance of Wnt inhibitory factor 1, a secreted protein controlling the Wnt and hedgehog pathways.

Wnts and Hedgehogs (Hh) are large, lipid-modified extracellular morphogens that play key roles in embryonic development and stem cell proliferation of Metazoa. Both morphogens signal through heptahelical Frizzled-type receptors of the G-Protein Coupled Receptor family and there are several other similarities that suggest a common evolutionary origin of the Hh and Wnt pathways. There is evidence that the secreted protein, Wnt inhibitory factor 1 (WIF1) modulates the activity of both Wnts and Hhs and may thus contribute to the intertwining of these pathways. In this article, we review the structure, evolution, molecular interactions and functions of WIF1 with major emphasis on its role in carcinogenesis.

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来源期刊

Growth factors 生物-内分泌学与代谢

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications