先进的蛋白质组学方法揭示蛋白质稳态

Q1 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Technologies Pub Date : 2019-04-01 DOI:10.1016/j.ddtec.2019.02.001

Paola Grandi, Marcus Bantscheff

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引用次数: 13

摘要

定量蛋白质组学方法有助于测量不同条件下细胞和组织中蛋白质合成和蛋白质降解之间的相互作用，并有助于理解蛋白质稳态的控制机制。蛋白质组学和化学蛋白质组学方法能够表征用于治疗应用的蛋白质降解的小分子修饰剂。在这里，我们回顾了基于质谱(化学)蛋白质组学方法在细胞稳态研究中的最新进展和应用。

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Advanced proteomics approaches to unravel protein homeostasis

Quantitative proteomics methods are instrumental in measuring the interplay between protein synthesis and protein degradation in cells and tissues in different conditions and substantially contribute to the understanding of control mechanisms for protein homeostasis. Proteomics and chemoproteomics approaches enable the characterization of small molecule modifiers of protein degradation for therapeutic applications. Here, we review recent developments and applications of mass spectrometry-based (chemo-)proteomics methods for the study of cellular homeostasis.

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来源期刊

Drug Discovery Today: Technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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发文量

期刊介绍： Discovery Today: Technologies compares different technological tools and techniques used from the discovery of new drug targets through to the launch of new medicines.