Alveolar Ridge Preservation Using Autologous Demineralized Tooth Matrix and Platelet-Rich Fibrin Versus Platelet-Rich Fibrin Alone: A Split-Mouth Randomized Controlled Clinical Trial.

Objective: To assess the potential of using autologous demineralized tooth matrix (aDTM) in combination with platelet-rich fibrin (PRF) membrane (aDTM/PRF) or PRF membrane alone (control) to preserve the ridge dimension and facilitate bone healing after tooth extraction.

Materials and methods: Forty premolar sockets were assigned to either the aDTM/PRF or control group. Horizontal and vertical ridge changes were evaluated at the baseline 2, 4, 6, and 8 weeks using cast-based and periapical radiographs.

Results: aDTM was well tolerated in all sites without incidences of postoperative complication. The change in horizontal ridge width was significantly greater in the control compared with the aDTM/PRF group. The overall vertical marginal bone resorption on the mesial, distal, and central site in the aDTM/PRF group was not statistically different from the control group. During the first 6 weeks, the bone healing density in the aDTM/PRF group was significantly higher than that of the control group, then it converged at week 8.

Conclusion: Application of aDTM with PRF membrane is useful for ridge preservation by reducing the horizontal ridge collapse and promoting bone healing as shown clinically and radiographically.