白细胞介素-11在疾病中的新作用。

IF 1.8 4区生物学 Q4 CELL BIOLOGY

Growth factors Pub Date : 2019-04-01 Epub Date: 2019-06-04 DOI:10.1080/08977194.2019.1620227

Paul M Nguyen, Suad M Abdirahman, Tracy L Putoczki

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引用次数: 26

摘要

白细胞介素(IL)-11属于IL-6细胞因子家族，发现于30多年前。虽然早期的研究集中在IL-11刺激巨核细胞生成的能力上，但这种细胞因子对炎症性疾病和癌症的重要性才刚刚开始被发现。本文概述了我们对IL-11生物学的最新理解，并强调了在多种疾病中具有临床靶向这种细胞因子信号传导潜力的新治疗方法的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging roles for Interleukin-11 in disease.

Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases.

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来源期刊

Growth factors 生物-内分泌学与代谢

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications