Perampanel:与MELAS综合征相关的难治性癫痫持续状态的治疗选择

Epilepsy and Behavior Case Reports Pub Date : 2019-01-01 DOI:10.1016/j.ebcr.2019.01.008

Estevo Santamarina , Alicia Alpuente , Olga Maisterra , María Sueiras , Silvana Sarria , Lorena Guzman , Laura Abraira , Javier Salas-Puig , Manuel Toledo

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引用次数: 13

摘要

据我们所知，没有与线粒体疾病相关的癫痫持续状态(SE)并使用perampanel (PER)治疗的报道。我们报告了三例难治性SE合并MELAS综合征的患者，他们对PER反应良好。所有病例均诊断为非惊厥性SE(局灶性，意识水平无损害)。在最初使用其他抗癫痫药物治疗后，所有病例均添加PER(8、16和12 mg)，并在接下来的4-8小时内观察到SE的停止。所有病例均有脑MRI显示的脑卒中样病变。在我们的患者中，PER是MELAS综合征相关SE的有效选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

$Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome$

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Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome

To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER.

All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI.

In our patients, PER was an effective option in SE associated with MELAS syndrome.

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Epilepsy and Behavior Case Reports

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