set结构域蛋白SET-25和SET-32的研究揭示了跨代表观遗传是一个多步骤的过程。

IF 3.2 Q2 GENETICS & HEREDITY

Epigenetics Insights Pub Date : 2019-04-15 eCollection Date: 2019-01-01 DOI:10.1177/2516865719844214

Rachel M Woodhouse, Alyson Ashe

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引用次数: 6

摘要

现在很清楚，遗传不是完全由孟德尔遗传决定的;有时，表观遗传信号可以从父母传给后代多代。这种现象被称为跨代表观遗传(TEI)，目前已经在包括植物、苍蝇、老鼠和线虫在内的多种生物中观察到这种例子。在这里，我们讨论了最近的发现，即TEI是一个多步骤的过程，并且假定的染色质修饰剂SET-25和SET-32在沉默的建立中很重要，但不是维持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Transgenerational Epigenetic Inheritance Is Revealed as a Multi-step Process by Studies of the SET-Domain Proteins SET-25 and SET-32.

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Transgenerational Epigenetic Inheritance Is Revealed as a Multi-step Process by Studies of the SET-Domain Proteins SET-25 and SET-32.

It is now clear that heredity is not determined purely by Mendelian genetic inheritance; sometimes, epigenetic signals can be passed from parent to progeny for multiple generations. This phenomenon is termed transgenerational epigenetic inheritance (TEI), and examples have now been observed in multiple organisms including plants, flies, mice, and nematodes. Here we discuss the recent findings that TEI is a multi-step process and that the putative chromatin modifiers SET-25 and SET-32 are important in the establishment but not maintenance of silencing.

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来源期刊

Epigenetics Insights GENETICS & HEREDITY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

8 weeks