微流体学研究结晶原理的进展。

IF 7.6 2区工程技术 Q1 CHEMISTRY, APPLIED

Annual review of chemical and biomolecular engineering Pub Date : 2019-06-07 Epub Date: 2019-04-24 DOI:10.1146/annurev-chembioeng-060718-030312

Nadine Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler

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引用次数: 12

摘要

本文综述了基于液滴的微流体系统在化学和生物学结晶基础研究中的应用。提出了一种新颖的高通量液滴微流控平台。它使用纳升液滴，生成化学库，直接溶解粉末，节省材料和时间。与所有溶剂兼容，不需要表面活性剂。它的灵活性允许相图测定和结晶研究(筛选和优化实验)，并使其易于用于微流体非专业人士。此外，它允许浓度测量通过紫外光谱和固体表征通过x射线衍射分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in the Use of Microfluidics to Study Crystallization Fundamentals.

This review compares droplet-based microfluidic systems used to study crystallization fundamentals in chemistry and biology. An original high-throughput droplet-based microfluidic platform is presented. It uses nanoliter droplets, generates a chemical library, and directly solubilizes powder, thus economizing both material and time. It is compatible with all solvents without the need for surfactant. Its flexibility permits phase diagram determination and crystallization studies (screening and optimizing experiments) and makes it easy to use for nonspecialists in microfluidics. Moreover, it allows concentration measurement via ultraviolet spectroscopy and solid characterization via X-ray diffraction analysis.

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来源期刊

Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL

CiteScore

16.00

自引率

0.00%

发文量

期刊介绍： The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.