Netrin家族:蛋白质亚型在癌症中的作用。

IF 1.3 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Nucleic Acids Pub Date : 2019-02-24 eCollection Date: 2019-01-01 DOI:10.1155/2019/3947123

Caroline Suzanne Bruikman, Huayu Zhang, Anneli Maite Kemper, Janine Maria van Gils

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引用次数: 22

摘要

网蛋白构成了一个分泌蛋白和膜相关蛋白家族。网络通过调节细胞迁移和存活，参与轴突引导、形态发生和血管生成等过程。这些过程在肿瘤生物学中具有特殊的意义。从网蛋白基因的各种异构体被翻译和调节的选择性剪接。我们在这里回顾了netrin家族成员的异构体的多样性及其在癌症中的已知和潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Netrin Family: Role for Protein Isoforms in Cancer.

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Netrin Family: Role for Protein Isoforms in Cancer.

Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing. We review here the diversity of isoforms of the netrin family members and their known and potential roles in cancer.

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来源期刊

Journal of Nucleic Acids BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.10

自引率

21.70%

发文量

审稿时长

12 weeks