方潭手术对器官系统的影响。

Q2 Medicine

Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2019-01-01 DOI:10.2174/1871529X19666190211165124

Miriam Michel, Manuela Zlamy, Andreas Entenmann, Karin Pichler, Sabine Scholl-Bürgi, Daniela Karall, Ralf Geiger, Christina Salvador, Christian Niederwanger, Hideo Ohuchi

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引用次数: 2

摘要

在接受Fontan手术的患者中，除了讨论得很好的心脏、肺和胃肠道系统的变化外，还报道了其他器官系统的变化，包括血液学、免疫、内分泌和代谢。作为Fontan手术的医学辅助，对肝脏作为代谢和合成器官的核心作用的系统研究应有助于更好地了解Fontan患者典型问题的病理机制，在此背景下，对内分泌和代谢模式的分析可能为优化Fontan随访、靶向监测和特异性辅助治疗提供工具。

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Impact of the Fontan Operation on Organ Systems.

In patients having undergone the Fontan operation, besides the well discussed changes in the cardiac, pulmonary and gastrointestinal system, alterations of further organ systems including the hematologic, immunologic, endocrinological and metabolic are reported. As a medical adjunct to Fontan surgery, the systematic study of the central role of the liver as a metabolizing and synthesizing organ should allow for a better understanding of the pathomechanism underlying the typical problems in Fontan patients, and in this context, the profiling of endocrinological and metabolic patterns might offer a tool for the optimization of Fontan follow-up, targeted monitoring and specific adjunct treatment.

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.