{"title":"沙漠植物 Warionia saharae 的黄酮类富集提取物能改善糖尿病大鼠的血糖和胆固醇水平","authors":"Mohammed Ajebli, Mohamed Eddouks","doi":"10.2174/1871525717666190121143934","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong><i>Warionia saharae</i> Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from <i>Warionia saharae</i> (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.</p><p><strong>Methods: </strong>Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and <i>in vitro</i> antioxidant activity of FEE were carried out in this study.</p><p><strong>Results: </strong>Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.</p><p><strong>Conclusion: </strong>In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.</p>","PeriodicalId":9535,"journal":{"name":"Cardiovascular and Hematological Agents in Medicinal Chemistry","volume":"17 1","pages":"28-39"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/f8/CHAMC-17-28.PMC6875866.pdf","citationCount":"0","resultStr":"{\"title\":\"Flavonoid-Enriched Extract from Desert Plant <i>Warionia saharae</i> Improves Glucose and Cholesterol Levels in Diabetic Rats.\",\"authors\":\"Mohammed Ajebli, Mohamed Eddouks\",\"doi\":\"10.2174/1871525717666190121143934\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objective: </strong><i>Warionia saharae</i> Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from <i>Warionia saharae</i> (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.</p><p><strong>Methods: </strong>Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and <i>in vitro</i> antioxidant activity of FEE were carried out in this study.</p><p><strong>Results: </strong>Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.</p><p><strong>Conclusion: </strong>In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.</p>\",\"PeriodicalId\":9535,\"journal\":{\"name\":\"Cardiovascular and Hematological Agents in Medicinal Chemistry\",\"volume\":\"17 1\",\"pages\":\"28-39\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/f8/CHAMC-17-28.PMC6875866.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular and Hematological Agents in Medicinal Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1871525717666190121143934\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular and Hematological Agents in Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871525717666190121143934","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats.
Background and objective: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.
Methods: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study.
Results: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.
Conclusion: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.
期刊介绍：
Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
