副作用评估及适当大小和年龄等效猪替代品与尺度人体副作用反应生物保真走廊的比较。

Q2 Medicine
Jennifer L Yaek, Christopher J Andrecovich, John M Cavanaugh, Stephen W Rouhana
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引用次数: 0

摘要

利用动物替代试验数据分析和验证当前的比例关系和现有的反应走廊是有价值的,并可能导致新的或改进的比例关系的发展。为此,研究人员对3岁、6岁、10岁和50百分位男性年龄相当的适当尺寸的猪尸体进行了侧摆冲击试验,并在胸部和腹部进行了试验,将猪的试验数据与已经建立的从50百分位成年男性到儿童水平的人类侧摆冲击反应走廊进行了比较,以确定当前比例法的可行性。根据人类3岁、6岁、10岁和第50百分位男性的整体体重,建立合适的猪代当量PSE。根据先前建立的横向冲击评估试验方案,进行了一系列横向冲击胸腹摆试验。PSE胸部和腹部撞击反应数据是根据先前建立的人类胸部横向撞击反应走廊和腹部斜向撞击反应走廊进行评估的,这些反应走廊分别针对3岁、6岁、10岁和50百分位的人类男性,基于侧摆撞击试验。目前研究的总体结果证实,为3岁、6岁、10岁和50岁成年男性建立的适当体重的猪代猪胸腹侧冲击力响应与先前建立的人类尺度侧冲击力响应走廊一致。猪替代生物力学测试可以证明是一种强有力的研究手段,可以进一步表征和理解损伤和侧碰撞反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Side Impact Assessment and Comparison of Appropriate Size and Age Equivalent Porcine Surrogates to Scaled Human Side Impact Response Biofidelity Corridors.

Analysis and validation of current scaling relationships and existing response corridors using animal surrogate test data is valuable, and may lead to the development of new or improved scaling relationships. For this reason, lateral pendulum impact testing of appropriate size cadaveric porcine surrogates of human 3-year-old, 6-year-old, 10-year-old, and 50th percentile male age equivalence, were performed at the thorax and abdomen body regions to compare swine test data to already established human lateral impact response corridors scaled from the 50th percentile human adult male to the pediatric level to establish viability of current scaling laws. Appropriate Porcine Surrogate Equivalents PSE for the human 3-year-old, 6-year-old, 10-year-old, and 50th percentile male, based on whole body mass, were established. A series of lateral impact thorax and abdomen pendulum testing was performed based on previously established scaled lateral impact assessment test protocols. The PSE thorax and abdominal impact response data were assessed against previously established scaled human thorax lateral impact response corridors and scaled abdominal oblique impact response corridors for the 3-year-old, 6-year-old, 10-year-old, and 50th percentile human male based on lateral pendulum impact testing. The overall findings of the current study confirm that lateral impact force response of the thorax and abdomen of appropriate weight porcine surrogates established for human-equivalent-age 3-year-old, 6-year-old, 10-year-old, and 50th adult male are consistent with the previously established human scaled lateral impact response corridors). Porcine surrogate biomechanics testing can prove to be a powerful research means to further characterize and understand injury and response in lateral impact.

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来源期刊
Stapp car crash journal
Stapp car crash journal Medicine-Medicine (all)
CiteScore
3.20
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