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引用次数: 7
摘要
肺部疾病是世界各地常见且重要的疾病和死亡原因。炎性小体已成为肺部疾病的重要调节因子。IL-1 β和IL-18在许多肺部疾病的炎症反应中的重要作用已被阐明。将IL-1 β和IL-18从它们的前体转化为活性形式的裂解受到炎症小体的严格调节。在本章中，我们从结构上回顾了目前关于炎症小体在急慢性肺部疾病发病机制中的相关成分的证据，重点是“炎症小体-caspase-1- il -1 β /IL-18”轴。
Inflammasome in the Pathogenesis of Pulmonary Diseases.
Lung diseases are common and significant causes of illness and death around the world. Inflammasomes have emerged as an important regulator of lung diseases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. The cleavage to turn IL-1 beta and IL-18 from their precursors into the active forms is tightly regulated by inflammasomes. In this chapter, we structurally review current evidence of inflammasome-related components in the pathogenesis of acute and chronic lung diseases, focusing on the "inflammasome-caspase-1-IL-1 beta/IL-18" axis.
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