有症状的原发性甲状旁腺功能亢进是分化型甲状腺癌症的危险因素。

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Thyroid Research Pub Date : 2018-11-18 eCollection Date: 2018-01-01 DOI:10.1155/2018/9461079
Guadalupe Vargas-Ortega, Lourdes Balcázar-Hernández, Baldomero González-Virla, Claudia Ramírez-Rentería, Oriana Nieto-Guzmán, Ana Pamela Garrido-Mendoza, Marco Antonio Flores-Maya, Moisés Mercado, Mendoza-Zubieta Victoria
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引用次数: 0

摘要

背景:原发性甲状旁腺功能亢进症(PHPT)是内分泌学家的常见疾病。伴发甲状腺疾病和分化型甲状腺癌症(DTC)在PHPT患者中似乎比普通人群更常见。本研究的目的是描述伴有和不伴有DTC的症状性PHPT患者的特征,并分析频率和危险因素。方法:我们连续研究了2013年至2015年间在我们中心诊断和治疗的有症状PHPT患者。排除亚临床和综合征型PHPT患者。比较了DTC患者和非DTC患者的临床和生化特征,并确定了危险因素。所有患者均接受甲状腺超声检查和TC-MIBI甲状腺造影检查。两位专业外科医生完成了所有的手术。结果:在纳入的59例患者中,我们发现了12例PTC(20.3%)。PTC的最终组织病理学报告为7例滤泡变异,2例嗜酸细胞变异,2例行变异和1例柱状细胞变异。患有甲状腺癌症的患者比没有患有甲状腺癌症的患者年龄大(62±9.5对52±15.8,p=0.03)。术前较高的iPTH水平与PTC相关(p=0.03)[OR 5.16(95%CI:1.08-24.7)]。有症状的PHPT患者的甲状腺结节必须在甲状旁腺切除术前进行研究。在有症状的PHPT中,甲状旁腺激素(PTH)浓度越高,患DTC的风险越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Symptomatic Primary Hyperparathyroidism as a Risk Factor for Differentiated Thyroid Cancer.

Background: The primary hyperparathyroidism (PHPT) is a common disease for the endocrinologist. The concomitant thyroid disease and differentiated thyroid cancer (DTC) appear to be more frequent in patients with PHPT than in the general population. The aim of this study was to characterize patients with symptomatic PHPT with and without DTC and analyze frequency and risk factors.

Methods: We consecutively studied patients with symptomatic PHPT diagnosed and treated at our center between 2013 and 2015. Patients with subclinical and syndromic forms of PHPT were excluded. Clinical and biochemical characteristics of patients with and without DTC were compared and risk factors were determined. All patients were studied with thyroid ultrasound and thyroid gammagraphy with TC-MIBI. Two expert surgeons performed all the surgical procedures.

Results: In 59 patients included, we found 12 cases of PTC (20.3%). The final histopathological report of the PTC was 7 cases of follicular variant, 2 cases of oncocytic variant, 2 cases of classic variant, and 1 case of columnar cells variant of PTC. Patients with thyroid cancer were older than patients without thyroid cancer (62 ± 9.5 versus 52 ± 15.8, p = 0.03). Higher preoperative levels of iPTH were associated with PTC (p=0.03) [OR 5.16 (95% CI: 1.08-24.7)].

Conclusion: PTC is frequent in patients with symptomatic PHPT. Thyroid nodules in patients with symptomatic PHPT must be studied before parathyroidectomy. In symptomatic PHPT, higher level concentration of parathormone (PTH) was associated with higher risk of DTC.

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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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