使用OmicsNet进行网络集成和三维可视化

Q1 Biochemistry, Genetics and Molecular Biology

Current protocols in bioinformatics Pub Date : 2018-12-17 DOI:10.1002/cpbi.69

Guangyan Zhou, Jianguo Xia

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引用次数: 39

摘要

OmicsNet是一个新颖的基于网络的工具，用于在3D空间中创建和可视化复杂的生物网络。通过将全面的知识库与强大的WebGL技术相结合，OmicsNet允许研究人员直观地探索基因、转录因子、microrna和代谢物之间的分子相互作用和调节关系。OmicsNet通过促进多组学集成和系统生物学填补了一个重要的空白。本文包含三个基本协议，涵盖OmicsNet的关键特性，包括如何从单个或多个分子列表创建生物网络，如何集成或丰富不同类型的网络，以及如何导航3D可视化系统以获得生物学见解。OmicsNet web服务器可在https://www.omicsnet.ca免费获得。©2018 by John Wiley &儿子,Inc。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Using OmicsNet for Network Integration and 3D Visualization

OmicsNet is a novel web-based tool for creating and visualizing complex biological networks in 3D space. By coupling a comprehensive knowledgebase with the powerful WebGL technology, OmicsNet allows researchers to intuitively explore molecular interactions and regulatory relationships among genes, transcription factors, microRNAs, and metabolites. OmicsNet fills an important gap by facilitating multi-omics integration and systems biology. This article contains three basic protocols covering the key features of OmicsNet, including how to create biological networks from a single or multiple list(s) of molecules, how to integrate or enrich different types of networks, and how to navigate the 3D visualization system to obtain biological insights. The OmicsNet web server is freely available at https://www.omicsnet.ca. © 2018 by John Wiley & Sons, Inc.

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来源期刊

Current protocols in bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry

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期刊介绍： With Current Protocols in Bioinformatics, it"s easier than ever for the life scientist to become "fluent" in bioinformatics and master the exciting new frontiers opened up by DNA sequencing. Updated every three months in all formats, CPBI is constantly evolving to keep pace with the very latest discoveries and developments.