用酰胺鉴定Ugi和Passerini反应

Q1 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Technologies Pub Date : 2018-11-01 DOI:10.1016/j.ddtec.2018.09.001

Bo Huang, Sunliang Cui

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引用次数: 2

摘要

β-氨基酰胺和β-乙酰氧基酰胺是重要的生物学和药理单位，在学术界和工业界都占有特殊地位。开发一种制备它们的方法已经引起了人们的注意。氰化物具有亲核和亲电双重性质，类似于异腈。本文报道了在Ugi和Passerini反应的单反应物替代方法中，利用酰胺类化合物开发两种新的多组分反应，得到各种β-氨基酰胺和β-酰基酰胺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Homologation of Ugi and Passerini reactions using ynamides

Being important biological and pharmacological units, β-amino amides and β-acyloxy amides have a privileged position in both academia and industry. Developing a methods to prepare them has gained attention. Ynamides, which possess dual nucleophilic and electrophilic properties, are similar to isonitriles. In this review, usage of ynamides in the single reactant replacement approach of Ugi and Passerini reactions to develop two new multicomponent reactions to get various β-amino amides and β-acyloxy amides is reported.

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来源期刊

Drug Discovery Today: Technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Discovery Today: Technologies compares different technological tools and techniques used from the discovery of new drug targets through to the launch of new medicines.