美沙酮、选择性血清素再摄取抑制剂与新生儿戒断综合征的关系。

IF 0.2 4区医学 Q4 Medicine

生殖医学杂志 Pub Date : 2016-09-01

Luis A Bracero, Michael Subit, Dara J Seybold, Morgan Vargo, Mike Broce

{"title":"美沙酮、选择性血清素再摄取抑制剂与新生儿戒断综合征的关系。","authors":"Luis A Bracero, Michael Subit, Dara J Seybold, Morgan Vargo, Mike Broce","doi":"","DOIUrl":null,"url":null,"abstract":"Objective: To compare incidence and severity of neo- natal abstinence syndrome (NAS) in neonates exposed to methadone and selective serotonin reuptake inhibitors (SSRIs) with neonates ex- posed to methadone alone.Study design: Retro- spective cohort study of women on methadone main- tenance with live births be- tween January 1, 2003, and December 31, 2009, at a tertiary care hospital. Data were abstracted from electronic medical records, exclud- ing cases of multiple gestations and lack of neonatal abstinence score documentation. Data analysis included Mann-Whitney U, Fisher's exact test, a receiver operat- ing characteristic curve, and a scatter diagram.Results: A total of 91 cases comprised our study population, with 85 (93.4%) assigned to the methadone- only group and 6 (6.6%) assigned to the methadone and SSRIs group. NAS incidence was not significantly different between the methadone/SSRI group and the methadone group (5/6 [83.3%] vs. 43/85 [50.6%], p=0.21). However, severity of NAS (median 14.0 vs. 10.0, p=0.04) and neonatal intensive care unit stay were significantly higher and longer in the methadone/ SSRI group.Conclusion: While currently neonates exposed to SSRIs are not screened for NAS, health care providers may need to pay closer attention to the effects of SSRIs on neonates.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"61 9-10","pages":"463-468"},"PeriodicalIF":0.2000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship Between Methadone, Selective Serotonin Reuptake Inhibitors, and Neonatal Abstinence Syndrome.\",\"authors\":\"Luis A Bracero, Michael Subit, Dara J Seybold, Morgan Vargo, Mike Broce\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To compare incidence and severity of neo- natal abstinence syndrome (NAS) in neonates exposed to methadone and selective serotonin reuptake inhibitors (SSRIs) with neonates ex- posed to methadone alone.Study design: Retro- spective cohort study of women on methadone main- tenance with live births be- tween January 1, 2003, and December 31, 2009, at a tertiary care hospital. Data were abstracted from electronic medical records, exclud- ing cases of multiple gestations and lack of neonatal abstinence score documentation. Data analysis included Mann-Whitney U, Fisher's exact test, a receiver operat- ing characteristic curve, and a scatter diagram.Results: A total of 91 cases comprised our study population, with 85 (93.4%) assigned to the methadone- only group and 6 (6.6%) assigned to the methadone and SSRIs group. NAS incidence was not significantly different between the methadone/SSRI group and the methadone group (5/6 [83.3%] vs. 43/85 [50.6%], p=0.21). However, severity of NAS (median 14.0 vs. 10.0, p=0.04) and neonatal intensive care unit stay were significantly higher and longer in the methadone/ SSRI group.Conclusion: While currently neonates exposed to SSRIs are not screened for NAS, health care providers may need to pay closer attention to the effects of SSRIs on neonates.\",\"PeriodicalId\":50063,\"journal\":{\"name\":\"生殖医学杂志\",\"volume\":\"61 9-10\",\"pages\":\"463-468\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2016-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"生殖医学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"生殖医学杂志","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

目的:比较美沙酮联合选择性5 -羟色胺再摄取抑制剂(SSRIs)与单纯美沙酮联合用药新生儿新生儿戒断综合征(NAS)的发生率和严重程度。研究设计:回顾性队列研究，研究对象为2003年1月1日至2009年12月31日在一家三级保健医院接受美沙酮维持治疗的活产妇女。数据从电子病历中提取，排除了多胎妊娠和缺乏新生儿戒断评分文件的病例。数据分析包括Mann-Whitney U, Fisher精确检验，接收者工作特性曲线和散点图。结果:我们的研究人群共有91例，其中85例(93.4%)分配给美沙酮组，6例(6.6%)分配给美沙酮和SSRIs组。美沙酮/SSRI组与美沙酮组NAS发生率差异无统计学意义(5/6[83.3%]比43/85 [50.6%]，p=0.21)。然而，NAS的严重程度(中位数14.0比10.0,p=0.04)和新生儿重症监护病房的住院时间在美沙酮/ SSRI组显著更高和更长。结论:虽然目前暴露于SSRIs的新生儿没有筛查NAS，但卫生保健提供者可能需要更密切地关注SSRIs对新生儿的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Relationship Between Methadone, Selective Serotonin Reuptake Inhibitors, and Neonatal Abstinence Syndrome.

Objective: To compare incidence and severity of neo- natal abstinence syndrome (NAS) in neonates exposed to methadone and selective serotonin reuptake inhibitors (SSRIs) with neonates ex- posed to methadone alone.

Study design: Retro- spective cohort study of women on methadone main- tenance with live births be- tween January 1, 2003, and December 31, 2009, at a tertiary care hospital. Data were abstracted from electronic medical records, exclud- ing cases of multiple gestations and lack of neonatal abstinence score documentation. Data analysis included Mann-Whitney U, Fisher's exact test, a receiver operat- ing characteristic curve, and a scatter diagram.

Results: A total of 91 cases comprised our study population, with 85 (93.4%) assigned to the methadone- only group and 6 (6.6%) assigned to the methadone and SSRIs group. NAS incidence was not significantly different between the methadone/SSRI group and the methadone group (5/6 [83.3%] vs. 43/85 [50.6%], p=0.21). However, severity of NAS (median 14.0 vs. 10.0, p=0.04) and neonatal intensive care unit stay were significantly higher and longer in the methadone/ SSRI group.

Conclusion: While currently neonates exposed to SSRIs are not screened for NAS, health care providers may need to pay closer attention to the effects of SSRIs on neonates.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

生殖医学杂志医学-妇产科学

自引率

0.00%

发文量

6427

审稿时长

6-12 weeks

期刊介绍： The Journal of Reproductive Medicine® has been the essential tool of Obstetricians and Gynecologists since 1968. As a highly regarded professional journal and the official periodical of six medical associations, JRM® brings timely and relevant information on the latest procedures and advances in the field of reproductive medicine. Published bimonthly, JRM® contains peer-reviewed articles and case reports submitted by top specialists. Common topics include research, clinical practice, and case reports related to general obstetrics and gynecology, infertility, female cancers, gynecologic surgery, contraception, and medical education.