生长激素和胰岛素样生长因子- 1测定的标准化。

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2018-09-01 DOI:10.17458/per.vol16.2018.k.standardizationmeasurementgh

Noriyuki Katsumata

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引用次数: 3

摘要

测定血清GH和igf - 1水平对于GH缺乏和与GH过量相关的疾病(如肢端肥大症和垂体巨人症)的诊断和治疗至关重要。然而，在世界范围内观察到不同方法测量的生长激素值存在显著差异。在日本，生长科学基金会的生长激素及其相关因素研究委员会通过创建公式将各种市售生长激素测定试剂盒测量的生长激素值调整为平均值，从而对生长激素值进行了标准化。委员会还确定了从儿童到成年的所有年龄段的日本受试者中igf - 1的参考值。在国际上，合作者一直致力于协调生长激素测量。

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Standardization of Growth Hormone and Insulin-like Growth Factor-I Measurement.

Determination of serum levels of GH and IGF-I is crucial for the diagnosis and treatment of GH deficiency and disorders related to GH excess such as acromegaly and pituitary gigantism. However, significant discrepancies in measured GH values among the methods were observed around the world. In Japan, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science standardized GH values measured with various commercially available GH assay kits by creating formulas to adjust them to their averages. The committee also established reference values for IGF-I in Japanese subjects at all ages from childhood to adulthood. Internationally, collaborators have been working on the harmonization of GH measurements.

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来源期刊

Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.