Magdalena Tormanowska, Tomasz Dzieciątkowski, Sylwia Rynans, Maciej Przybylski, Anna Gronkowska, Grzegorz W Basak, Graźyna Młynarczyk, Agnieszka Tomaszewska
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引用次数: 0
摘要
IgM和IgG类特异性抗hhv -6抗体和病毒DNA。定量实时PCR法也用于测定血浆样本中同种异体造血干细胞受体的病毒载量。结果:实验组所有个体移植前均无抗hhv -6的IgM抗体。在移植前，54名供者中的38名(70%)和54名受者中的47名(870/o)分别检测到特异性igg类抗hhv -6抗体。在54名受者中，仅一人(1.9%)的血浆样本中检测到高负荷的HHV-6 DNA (>1x10A6拷贝/ml)。结论:波兰患者中存在高频特异性抗hhv -6抗体;除此之外，CI-HHV-6很少被检测到。尽管如此，我们还是强烈建议仔细观察那些被认为携带CI-HHV-6的血液恶性肿瘤患者。为了确定CI-HHV-6在同种异体移植受者中的明确作用，需要进一步开展更大规模的研究。
[Prevalence of CI-HHV-6 in patients with hematological diseases and healthy donors in Poland - preliminary study].
of specific anti-HHV-6 antibodies in IgM and IgG classes and viral DNA. Quantitative real-time PCR assay was also used to determine viral load in alloHSCT recipients in plasma samples. Results: All individuals from studied group have not IgM antibodies against-HHV-6 prior transplantation. Specific IgG-class anti-HHV-6 antibodies were detected in 38 of 54 (70%) donors and in 47 of 54 recipients before HSCT (870/o), respectively. High load of HHV-6 DNA (>1x10A6 copies/ml) was detected in plasma samples taken only from one person (1,9%) of the 54 recipients. Conclusions: There is a high frequency specific anti-HHV-6 antibody in studied Polish patients; otherwise CI-HHV-6 was rare detected. Nonetheless, we urge careful observation of individuals with hematological malignances supposed to have CI-HHV-6. Further research on larger study group is needed to determine the clear role of CI-HHV-6 in alloHSCT recipients.
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