T G Kutlina, R R Galimova, M M Shaymukhametova, G F Muchammadiyeva, A B Bakirov, D O Karimov
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引用次数: 0
摘要
目的:本研究旨在调查巴什科尔托斯坦共和国肝胆系统病变(PHS)患者和健康人群中CYP2E1和GSTA1基因多态性变异的频率，并分析该基因的基因型与PHS发展的可能关联。材料与方法:对81例肝胆系统病理患者进行检查。研究了基因CYP2E1和GSTA1多态性位点的关联分析。结果:AA基因型是本病发生风险的标志之一(OR = 2,09;(95% CI 1,07-4,10)多态性位点基因rs3957357 GSTA1。
[GENETIC PREDISPOSITION TO DEVELOPMENT OF TOXIC HEPATITIS].
Aim: The aim of this study was to investigate the frequency of polymorphic variants of genes CYP2E1 and GSTA1 in patients with pathology of the hepatobiliary system (PHS) and healthy individuals in the Republic of Bashkortostan, as well as an analysis of possible associations of genotypes of this gene with the development of PHS.
Materials and methods: There were examined 81 patients with pathology of the hepatobiliary system. Was studied association analysis of polymorphic loci of genes CYP2E1 and GSTA1.
Results: The study demonstrated that a marker of risk of developing the disease is AA genotype (OR = 2,09; 95% CI 1,07-4,10) polymorphic locus gene rs3957357 GSTA1.
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