{"title":"LKB1激活的新机制。","authors":"Szu-Wei Lee, Hui-Kuan Lin","doi":"10.1080/23723556.2015.1035691","DOIUrl":null,"url":null,"abstract":"<p><p>Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) has been thought to be a constitutively active tumor suppressor that is activated by forming an active complex. Very recently, a new post-translational modification on LKB1 was identified that can regulate LKB1 activation and LKB1-mediated cancer cell survival under energy stress.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"e1035691"},"PeriodicalIF":0.0000,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2015.1035691","citationCount":"5","resultStr":"{\"title\":\"A new mechanism for LKB1 activation.\",\"authors\":\"Szu-Wei Lee, Hui-Kuan Lin\",\"doi\":\"10.1080/23723556.2015.1035691\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) has been thought to be a constitutively active tumor suppressor that is activated by forming an active complex. Very recently, a new post-translational modification on LKB1 was identified that can regulate LKB1 activation and LKB1-mediated cancer cell survival under energy stress.</p>\",\"PeriodicalId\":520710,\"journal\":{\"name\":\"Molecular & cellular oncology\",\"volume\":\" \",\"pages\":\"e1035691\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/23723556.2015.1035691\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & cellular oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23723556.2015.1035691\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & cellular oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23723556.2015.1035691","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) has been thought to be a constitutively active tumor suppressor that is activated by forming an active complex. Very recently, a new post-translational modification on LKB1 was identified that can regulate LKB1 activation and LKB1-mediated cancer cell survival under energy stress.
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