他汀类药物和骨骼健康:一个小回顾。

IF 0.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Actualizaciones en Osteologia Pub Date : 2018-01-01

Leslie R Morse, Jennifer Coker, Ricardo A Battaglino

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引用次数: 0

摘要

他汀类药物是一种广泛使用的药物，它可以抑制与抗吸收双膦酸盐药物相似的途径。他汀类药物通过阻断HMG-CoA还原酶靶向甲羟戊酸途径。最近的几项荟萃分析得出结论，他汀类药物在一般人群中具有骨保护作用。在这里，我们介绍了目前的文献，探讨他汀类药物可能的骨保护作用的机制。我们还回顾了最近的临床研究，从观察性队列研究到随机临床试验，测试了他汀类药物对不同人群骨骼健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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STATINS AND BONE HEALTH: A MINI REVIEW.

Statins are a widely prescribed class of medications that inhibit similar pathways as the anti-resorptive bisphosphonate drugs. Statins target the mevalonate pathway by blocking HMG-CoA reductase. Several recent meta-analyses concluded statins are osteoprotective in the general population. Here we present current literature exploring the mechanisms underlying the putative osteoprotective effects of statins. We also review recent clinical studies, ranging from observational cohort studies to randomized clinical trials, testing the effect of statins on bone health in various populations.

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来源期刊

Actualizaciones en Osteologia MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

0.10

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0.00%

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