补充鱼油 omega-3 脂肪酸对多囊卵巢综合征患者精神健康参数和代谢状态的影响:随机、双盲、安慰剂对照试验。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Mehrdad Amini, Fereshteh Bahmani, Fatemeh Foroozanfard, Zahra Vahedpoor, Amir Ghaderi, Mohsen Taghizadeh, Hassan Karbassizadeh, Zatollah Asemi
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引用次数: 0

摘要

研究目的本研究旨在评估补充鱼油欧米加-3 脂肪酸对多囊卵巢综合征(PCOS)女性心理健康参数和代谢状况的影响:这项随机双盲安慰剂对照试验针对 60 名患有多囊卵巢综合征的女性进行,她们的年龄在 18-40 岁之间。参与者被随机分为两组,每天午餐后服用 2 × 1000 毫克鱼油欧米伽-3 脂肪酸(30 人)或安慰剂(30 人),连续服用 12 周。对基线和 12 周干预后的代谢状况进行量化:与安慰剂相比,摄入欧米伽-3 脂肪酸可显著改善贝克抑郁量表(Beck Depression Inventory)[β(干预后治疗组之间平均结果测量值的差异)-1.05;95% CI:-1.84,-0.26;p = .01]、一般健康问卷(β-1.68;95% CI:-3.12,-0.24;p = .02)和抑郁、焦虑和压力量表(β-2.03;95% CI:-3.60,-0.46;p = .01)。补充欧米伽-3 脂肪酸可显著降低血清胰岛素水平(β -2.09 µIU/mL; 95% CI: -3.77, -0.41; p = .01)、胰岛素抵抗平衡模型评估(β -0.74; 95% CI: -1.13, -0.34; p 结论:补充欧米伽-3 脂肪酸可显著降低血清胰岛素水平:总体而言,多囊卵巢综合征患者连续 12 周补充欧米伽-3 脂肪酸对心理健康参数、胰岛素代谢、总睾酮、多毛症以及一些炎症指标和氧化应激均有益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retracted article: The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.

We, the Editor and Publisher of the Journal of Psychosomatic Obstetrics & Gynecology have retracted the following article:Mehrdad Amini, Fereshteh Bahmani, Fatemeh Foroozanfard, Zahra Vahedpoor, Amir Ghaderi, Mohsen Taghizadeh, Hassan Karbassizadeh & Zatollah Asemi (2018), The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Psychosomatic Obstetrics & Gynecology, DOI: 10.1080/0167482X.2018.1508282.Following publication, significant concerns were raised by a third party 1 about the integrity of the data and the reported findings in the article.When approached for an explanation, the authors and their institution have been cooperative in providing some responses and documents. To verify the reported findings, the article and the documents provided by the authors were further evaluated by the journal editorial team, and also sent for review by an external statistical reviewer.Both the journal editorial team and the external statistical reviewer were unable to confirm the integrity of the trial design and the main outcome of the external review was that the article's results and conclusions are unreliable. Therefore, as the editorial team no longer have confidence in the reported conclusions the decision has been made to retract the article.The authors listed in the publication have been informed. The authors do not agree with the retraction.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.

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来源期刊
CiteScore
6.10
自引率
3.20%
发文量
54
审稿时长
>12 weeks
期刊介绍: The Journal of Psychosomatic Obstetrics and Gynecology was founded in 1982 in order to provide a scientific forum for obstetricians, gynecologists, psychiatrists and psychologists, academic health professionals as well as for all those who are interested in the psychosocial and psychosomatic aspects of women’s health. Another of its aims is to stimulate obstetricians and gynecologists to pay more attention to this very important facet of their profession.
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