提交原始生殖细胞:一个更新的分子视角。

IF 7.9 Q1 Medicine
Haihan Tan, Wee-Wei Tee
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引用次数: 17

摘要

生殖系是一个重要的细胞谱系,不同于体细胞,并完全负责遗传信息的跨代传递在后生动物有性生殖。原始生殖细胞(PGCs)是功能生殖细胞的前体,是胚胎发育过程中最早分配的细胞类型之一,这种谱系承诺是生殖系和体细胞组织分化的关键事件。传统上,哺乳动物PGC的发展在很大程度上是通过对小鼠胚胎和胚胎干细胞的研究来了解的。然而,最近来自相应的非啮齿动物系统的研究结果表明,小鼠PGC规范可能不完全是原型。在这篇综述中,我们概述了目前对PGC规范的分子机制的理解,强调了关键的转录事件,并关注早期人类和小鼠PGC承诺的显着差异。除了这些最新的发现之外,我们还考虑了这一领域研究的未来前景,强调全面理解早期命运决定的重要性,这些决定是这一独特谱系隔离的基础。本文分类如下:发育生物学>干细胞生物学与再生生物学机制>细胞命运生理学>健康与疾病中的哺乳动物生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Committing the primordial germ cell: An updated molecular perspective.

The germ line is a crucial cell lineage that is distinct from somatic cells, and solely responsible for the trans-generational transmission of hereditary information in metazoan sexual reproduction. Primordial germ cells (PGCs)-the precursors to functional germ cells-are among the first cell types to be allocated in embryonic development, and this lineage commitment is a critical event in partitioning germ line and somatic tissues. Classically, mammalian PGC development has been largely informed by investigations on mouse embryos and embryonic stem cells. Recent findings from corresponding nonrodent systems, however, have indicated that murine PGC specification may not be fully archetypal. In this review, we outline the current understanding of molecular mechanisms in PGC specification, emphasizing key transcriptional events, and focus on salient differences between early human and mouse PGC commitment. Beyond these latest findings, we also contemplate the future outlook of inquiries in this field, highlighting the importance of comprehensively understanding early fate decisions that underlie the segregation of this unique lineage. This article is categorized under: Developmental Biology > Stem Cell Biology and Regeneration Biological Mechanisms > Cell Fates Physiology > Mammalian Physiology in Health and Disease.

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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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