分子成像技术在神经毒理学研究中的应用。

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-01-01 Epub Date: 2018-09-10 DOI:10.1080/10590501.2018.1492200

Xuan Zhang, Qi Yin, Marc Berridge, Che Wang

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引用次数: 1

摘要

分子影像学在临床前研究中得到了广泛的应用。在这些新的分子成像方式中，微pet成像可以作为一种非常强大的工具，可以在同一受试者的不同器官中重复获得多种生物过程的测量。本文讨论了这种新方法如何为神经毒理学研究提供无创生物标志物，并总结了微pet与多种放射性示踪剂在啮齿动物和非人灵长类动物大脑中毒性物质诱导的各种神经毒性的研究结果。

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Application of molecular imaging technology in neurotoxicology research.

Molecular imaging has been widely applied in preclinical research. Among these new molecular imaging modalities, microPET imaging can be utilized as a very powerful tool that can obtain the measurements of multiple biological processes in various organs repeatedly in a same subject. This review discusses how this new approach provides noninvasive biomarker for neurotoxicology research and summarizes microPET findings with multiple radiotracers on the variety of neurotoxicity induced by toxic agents in both the rodent and the nonhuman primate brain.

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来源期刊

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews 环境科学-毒理学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.