[毛蕊红杜根的化学成分]。

中药材 Pub Date : 2016-06-01

Yun-ting Cai, Hua-wei Geng

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引用次数: 0

摘要

目的:研究毛蕊红根的化学成分及其抗肿瘤活性。方法:采用多种柱层析技术分离化合物。通过理化性质和光谱数据对其结构进行了表征。此外，采用MTT法评价其对黑色素瘤SK-MEI-110细胞的抗肿瘤活性。结果:从毛蕊红柱根中分离得到13个化合物，结构分别为:2α， 3β，23-三羟基齐墩酸-11,13(18)-二烯-28-果酸(1)，3β，23-二羟基齐墩酸-18-烯-28-果酸(2)，芦皮醇(3)，桦木素(4)，桦木酸(5)，木质素(6)，β-谷甾醇(7)，thero- 2,3 -二-(4-羟基-3-甲氧基苯基)-3-甲氧基丙醇(8)，evafolin B(9)， β-羟基丙香酮(10)，8,8′-二氢松柏基)-二铁酸酯(11)，没食子酸(12)和没食子酸甲酯(13)。结论:化合物1、2、8 ~ 10和13为首次从该植物中分离得到。化合物1 ~ 6对黑色素瘤SK-MEL-110细胞有抑制作用。

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[Chemical Constituents from the Roots of Rhodomyrtus tomentosa].

Objective: To investigate the chemical constituents of the roots of Rhodomyrtus tomentosa and their antitumor activities.

Methods: Various column chromatographic techniques were used to isolate the compounds. The structures were elucidated by their physicochemical properties and spectra data. Moreover, MTT assay was used to evaluate the antitumor activity against melanoma SK-MEI-110 cells.

Results: Thirteen compounds were obtained from the roots of Rhodomyrtus tomentosa, and their structures were determined as 2α, 3β, 23-trihydroxyoleana-11,13( 18)-dien-28-oic acid( 1),3β,23-dihydroxyolean-18-en-28-oic acid( 2), lupeol( 3), betulin( 4), betulinic acid( 5), friedelin( 6), β-sitosterol( 7), thero-2, 3-bis-( 4-hydroxy-3-methoxypheyl)-3-methoxy-propanol( 8), evafolin B( 9), β-hydroxypropiovanillone ( 10), 8, 8’-bis-( dihydroconiferyl)-diferuloylate( 11), gallate acid( 12) and methyl gallate( 13).

Conclusion: Compounds 1,2,8 ~ 10 and 13 are isolated from this plant for the first time. Compounds 1 ~ 6 exhibite inhibitory effects on melanoma SK-MEL-110 cells.

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来源期刊

中药材

自引率

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发文量

11364

期刊介绍： "Chinese Materia Medica" magazine was founded in 1978. It is a national-level academic journal of Chinese medicine science and technology approved by the State Science and Technology Commission and the Press and Publication Administration for public distribution at home and abroad. It is sponsored by the Chinese Materia Medica Information Center of the State Food and Drug Administration and is publicly distributed at home and abroad. It mainly reports on new technologies, new methods and new achievements in the production, scientific research and business management of Chinese medicine, and serves to promote the production and scientific and technological development of Chinese medicine, improve the output and quality of Chinese medicine, improve business management, and prosper the Chinese medicine industry.