[中心设计-响应面法优化太白楤木磷脂复合物总皂苷的制备]。

中药材 Pub Date : 2016-06-01

Bing-tao Zhai, Jia Li, Xiao-li Liu, Wei-ping Yang, Bei Zheng, Ya-jun Shi, Dong-yan Guo

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引用次数: 0

摘要

目的:采用中心设计-响应面法优化太白楤木磷脂复合物(TSAT-PC)总皂苷的制备工艺。方法:采用溶剂蒸发法制备太白楤木总皂苷磷脂复合物，考察了反应溶剂、反应时间、反应温度、反应物配比、药物浓度等5个因素对该反应的影响，然后采用中心复合设计响应面法对TSAT-PC的制备工艺进行优化，并对其理化性质进行研究。结果:最佳工艺条件为:反应时间为1 h，反应温度为45℃，大豆卵磷脂(SL)与TSAT的比例为3∶1，反应浓度为16 mg / m L，络合率为97。23%，与预测偏差小于5%;红外光谱分析证实了TSAT-PC的形成，其在辛醇中的溶解度高于原药。结论:经优化工艺制备出TSAT-PC，提高了其在辛醇中的溶解度，为中药材制剂的进一步开发利用提供参考。

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[Optimization on Preparation of Total Saponins of Aralia taibaiensis Phospholipid Complex by Central Composite Design-Response Surface Method].

Objective: To optimize the preparation of total saponins of Aralia taibaiensis phospholipid complex( TSAT-PC) by the central composite design-response surface method.

Methods: Total saponins of Aralia taibaiensis phospholipid complex was prepared by using solvent evaporation method, five factors including reaction solvent, reaction time, reaction temperature, ratio of reactants on this reaction, and the concentration of the drug were investigated, then to optimize the preparation of TSAT-PC by the central composite design response surface method, and to study its physicochemical properties.

Results: The optimal process conditions were as follows, the reaction time was 1 h, the reaction temperature was 45 ℃,the ratio of soya lecithine ( SL) and TSAT was 3∶ 1, the reaction concentration was16 mg / m L, the complexing rate was 97. 23%,it was less than 5% with the predicted deviation; IR analysis proved the formation of TSAT-PC, and the solubility in the octyl alcohol was higher than the original drug.

Conclusion: TSAT-PC was successfully developed by the optimized process, enhance the solubility in octyl alcohol, which provide the reference for the further development and utilization of Chinese materia medica preparation.

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来源期刊

中药材

自引率

0.00%

发文量

11364

期刊介绍： "Chinese Materia Medica" magazine was founded in 1978. It is a national-level academic journal of Chinese medicine science and technology approved by the State Science and Technology Commission and the Press and Publication Administration for public distribution at home and abroad. It is sponsored by the Chinese Materia Medica Information Center of the State Food and Drug Administration and is publicly distributed at home and abroad. It mainly reports on new technologies, new methods and new achievements in the production, scientific research and business management of Chinese medicine, and serves to promote the production and scientific and technological development of Chinese medicine, improve the output and quality of Chinese medicine, improve business management, and prosper the Chinese medicine industry.