中枢神经系统轴突再生:面对来自内部的挑战。

IF 11.4 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology Pub Date : 2018-10-06 Epub Date: 2018-07-25 DOI:10.1146/annurev-cellbio-100617-062508

Michele Curcio, Frank Bradke

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引用次数: 120

摘要

成年哺乳动物中枢神经系统(CNS)损伤后，受损的轴突不能再生。这种再生的失败与轴突在胚胎发育和周围神经系统(PNS)损伤后的显著生长潜力形成对比。一些细胞内机制，包括细胞骨架动力学，轴突运输和运输，再生程序的信号和转录，以及表观遗传修饰，控制轴突再生。在这篇综述中，我们描述了如何操纵内在机制在不同的生物体中引发再生反应，以及如何实施策略以形成未来中枢神经系统损伤后再生治疗的基础。

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Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside.

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms-including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications-control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury.

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来源期刊

Annual review of cell and developmental biology 生物-发育生物学

CiteScore

19.50

自引率

0.00%

发文量

期刊介绍： The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.