【d -半乳糖致衰老大鼠模型的研究进展】

药学学报 Pub Date : 2017-03-01

Fan-fan Zhao, Yu-zhi Zhou, Li Gao, Xue-mei Qin, Guan-hua Du

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引用次数: 0

摘要

d -半乳糖(D-gal)诱导衰老模型广泛应用于抗衰老药物的药效学研究。模型具有寿命缩短、学习记忆障碍、免疫功能下降等衰老特征。定期定量注射d -半乳糖溶液可产生自然衰老模型的症状，可用于抗衰老药物的筛选及其药理活性。本文就d -半乳糖溶液致大鼠模型的机制作一综述。给出了老化模型的建立和评价方法。为后续衰老及抗衰老药物机制研究提供理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Advances in the study of the rat model of aging induced by D-galactose]

D-galactose (D-gal)-induced aging model is widely used in the study of the pharmacodynamics of antiaging drugs. The model has a shorter life-span, disorders in learning and memory, reduced immune function and other aging characteristics. Regular and quantitative injection of D-gal solution to rats can produce symptoms of natural aging models that are used in screening of antiaging drugs, and their pharmacological activities. This paper provides a summary of the mechanism of rat model induced with D-gal solution. The methods of building and evaluation of the aging models are provided. The theoretical basis is included to facilitate the subsequent research and experiment in the mechanism study of aging and antiaging medicines.

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.