S V Ziablitsev, S V Pishchulina, S V Kolesnikova, R N Boris, Yuzkiv Ya S
{"title":"实验性脑损伤中碳水化合物代谢紊乱。","authors":"S V Ziablitsev, S V Pishchulina, S V Kolesnikova, R N Boris, Yuzkiv Ya S","doi":"10.15407/fz62.04.018","DOIUrl":null,"url":null,"abstract":"<p><p>In experimental heavy closed brain injury (mortality infive days - 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3-3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic β-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 4","pages":"18-22"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Disorders of carbohydrate metabolism in experimental brain injury.\",\"authors\":\"S V Ziablitsev, S V Pishchulina, S V Kolesnikova, R N Boris, Yuzkiv Ya S\",\"doi\":\"10.15407/fz62.04.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In experimental heavy closed brain injury (mortality infive days - 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3-3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic β-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury.</p>\",\"PeriodicalId\":73031,\"journal\":{\"name\":\"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)\",\"volume\":\"62 4\",\"pages\":\"18-22\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15407/fz62.04.018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15407/fz62.04.018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Disorders of carbohydrate metabolism in experimental brain injury.
In experimental heavy closed brain injury (mortality infive days - 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3-3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic β-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury.
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