T M Falalyeyeva, I V Leschenko, T V Beregova, L M Lazarenko, O M Savchuk, L M Sichel, O I Tsyryuk, T B Vovk, M Ya Spivak
{"title":"乳酸杆菌和双歧杆菌的益生菌菌株改变了谷氨酸钠诱导的肥胖大鼠的促炎性和抗炎性细胞因子的产生。","authors":"T M Falalyeyeva, I V Leschenko, T V Beregova, L M Lazarenko, O M Savchuk, L M Sichel, O I Tsyryuk, T B Vovk, M Ya Spivak","doi":"10.15407/fz63.01.017","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro- and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing ofthe IL-4, IL-10 and tumor growthfactor (TGF)-β levels in the bloodserum. After administration of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition to obese rats the level of the IL-lP in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically signifcant difference comparing with intact rats. The level of the IL-12B p4O in blood serum was decreased under influence of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition (18.9%, p < 0.05) and B. animalis VKL (10.5%, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats ofthe B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition the levels ofthe IL-4, IL- 10 and TGF-β increased in blood serum comparing with obese rats, not receiving probiotic bacteria. The level of the IL-10 also increased under influence of the B. animalis VKB, and IL-4 - under influence of the L. casei IMVB-7280. Our results suggest that these probiotic bacteria and probiotic composition are able to down-regulation the inflammation in rats with MSG-induced obesity but the strongest anti-inflammatory effects have probiotic composition. The ability of lactobacilli and bifdobacteria to alter the pro- and anti-inflammatory cytokines production, opens perspectives to create new treatments for obesity and metabolic syndrome based on probiotics.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"63 1","pages":"17-25"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":"{\"title\":\"Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity.\",\"authors\":\"T M Falalyeyeva, I V Leschenko, T V Beregova, L M Lazarenko, O M Savchuk, L M Sichel, O I Tsyryuk, T B Vovk, M Ya Spivak\",\"doi\":\"10.15407/fz63.01.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro- and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing ofthe IL-4, IL-10 and tumor growthfactor (TGF)-β levels in the bloodserum. After administration of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition to obese rats the level of the IL-lP in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically signifcant difference comparing with intact rats. The level of the IL-12B p4O in blood serum was decreased under influence of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition (18.9%, p < 0.05) and B. animalis VKL (10.5%, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats ofthe B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition the levels ofthe IL-4, IL- 10 and TGF-β increased in blood serum comparing with obese rats, not receiving probiotic bacteria. The level of the IL-10 also increased under influence of the B. animalis VKB, and IL-4 - under influence of the L. casei IMVB-7280. Our results suggest that these probiotic bacteria and probiotic composition are able to down-regulation the inflammation in rats with MSG-induced obesity but the strongest anti-inflammatory effects have probiotic composition. 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引用次数: 15
摘要
本研究旨在探讨干酪乳杆菌IMV B-7280、动物双歧杆菌VKL、动物双歧杆菌VKB等益生菌菌株对味精诱导肥胖Wistar雄性大鼠促炎性和抗炎性细胞因子产生的影响。结果表明，新生期大鼠给予味精可导致血清中白细胞介素(IL)-1β和IL-12水平升高，IL-4、IL-10和肿瘤生长因子(TGF)-β水平降低。肥胖大鼠给予动物双歧杆菌VKL -动物双歧杆菌VKB -干酪双歧杆菌IMV B-7280组合物后，血清IL-lP水平与未给予益生菌的肥胖大鼠无明显差异。但与完整大鼠比较，差异无统计学意义。与未接种益生菌的肥胖大鼠相比，动物双歧杆菌VKL -动物双歧杆菌VKB -干酪双歧杆菌IMV B-7280组合物的血清IL-12B p40o水平降低(18.9%，p < 0.05)，动物双歧杆菌VKL降低(10.5%，p < 0.05)，但仍高于正常动物。肥胖大鼠给予B. animalis VKL - B. animalis VKB - L. casei IMV B-7280组合物后，血清IL-4、IL- 10和TGF-β水平较未给予益生菌的肥胖大鼠升高。IL-10和IL-4分别在动物双歧杆菌VKB和干酪双歧杆菌IMVB-7280的作用下升高。我们的研究结果表明，这些益生菌和益生菌成分能够降低msg诱导的肥胖大鼠的炎症反应，但益生菌成分的抗炎作用最强。乳酸菌和双歧杆菌改变促炎性和抗炎性细胞因子产生的能力，为基于益生菌的肥胖和代谢综合征的新治疗方法开辟了前景。
Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity.
The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro- and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing ofthe IL-4, IL-10 and tumor growthfactor (TGF)-β levels in the bloodserum. After administration of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition to obese rats the level of the IL-lP in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically signifcant difference comparing with intact rats. The level of the IL-12B p4O in blood serum was decreased under influence of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition (18.9%, p < 0.05) and B. animalis VKL (10.5%, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats ofthe B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition the levels ofthe IL-4, IL- 10 and TGF-β increased in blood serum comparing with obese rats, not receiving probiotic bacteria. The level of the IL-10 also increased under influence of the B. animalis VKB, and IL-4 - under influence of the L. casei IMVB-7280. Our results suggest that these probiotic bacteria and probiotic composition are able to down-regulation the inflammation in rats with MSG-induced obesity but the strongest anti-inflammatory effects have probiotic composition. The ability of lactobacilli and bifdobacteria to alter the pro- and anti-inflammatory cytokines production, opens perspectives to create new treatments for obesity and metabolic syndrome based on probiotics.
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