黑色素瘤治疗回顾。

IF 6.2 Q1 IMMUNOLOGY
ImmunoTargets and Therapy Pub Date : 2018-06-07 eCollection Date: 2018-01-01 DOI:10.2147/ITT.S134842
Beatriz Domingues, José Manuel Lopes, Paula Soares, Helena Pópulo
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引用次数: 435

摘要

黑色素瘤是最具侵袭性和最致命的皮肤癌。目前的治疗方法包括手术切除、化疗、光动力治疗、免疫治疗、生物化疗和靶向治疗。治疗策略可以包括单药或联合治疗,这取决于患者的健康状况、阶段和肿瘤的位置。由于各种耐药机制的发展,这些治疗的效率可能会降低。新的治疗靶点已经出现在黑素细胞的遗传谱的研究和从分子因素的鉴定参与恶性转化的发病机制。在这篇综述中,我们旨在调查已批准和正在评估的黑色素瘤治疗方法以及黑色素瘤发生的分子机制的相关研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Melanoma treatment in review.

Melanoma treatment in review.

Melanoma treatment in review.

Melanoma treatment in review.

Melanoma represents the most aggressive and the deadliest form of skin cancer. Current therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy, immunotherapy, biochemotherapy, and targeted therapy. The therapeutic strategy can include single agents or combined therapies, depending on the patient's health, stage, and location of the tumor. The efficiency of these treatments can be decreased due to the development of diverse resistance mechanisms. New therapeutic targets have emerged from studies of the genetic profile of melanocytes and from the identification of molecular factors involved in the pathogenesis of the malignant transformation. In this review, we aim to survey therapies approved and under evaluation for melanoma treatment and relevant research on the molecular mechanisms underlying melanomagenesis.

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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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