肌苷5′-单磷酸脱氢酶活性的测定及临床应用

药学学报 Pub Date : 2016-11-01

Fei-yan Liu, Xiao-yan Qiu, Zheng Jiao

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引用次数: 0

摘要

肌苷5′-单磷酸脱氢酶(IMPDH)是鸟嘌呤新生生物合成的限速酶，在细胞增殖中起重要作用。临床上，IMPDH抑制剂主要应用于抗癌、抗病毒、抗寄生虫、免疫抑制化疗等领域。然而，由于药物浓度与IMPDH抑制剂的临床效果之间通常存在较大的个体间和个体内差异，因此可以将IMPDH酶活性作为特异性生物标志物，并与药代动力学(PK)监测相结合，以提高IMPDH抑制剂的疗效和安全性。本文综述了近年来IMPDH活性测定方法及其临床应用，为开展IMPDH抑制剂的药效学监测提供有价值的见解和理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[The determination and clinical application of inosine 5’-monophosphate dehydrogenase activity].

Inosine 5’-monophosphate dehydrogenase(IMPDH) is a rate-limiting enzyme in de novo biosynthesis of guanine and plays an important role in cell proliferation. In clinic, IMPDH inhibitors are mainly used in fields of anticancer, antiviral, anti-parasitic, and immunosuppressive chemotherapy. However, since there are usually great inter- and intra-individual variability between drug concentration and clinical effect of IMPDH inhibitors, the enzyme activity of IMPDH may be applied as a specific biomarker and combined with the pharmacokinetics (PK) monitoring to improve efficacy and safety of IMPDH inhibitors. This review aims to discuss the assay of IMPDH activity measurement and its clinical application in recent years and provide valuable insights and theoretical basis for the development of IMPDH inhibitors’ pharmacodynamics monitoring.

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.