白细胞介素-10多态性与青少年特发性关节炎易感性之间的关系:一项系统综述和荟萃分析。

IF 2.2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

European cytokine network Pub Date : 2018-03-01 DOI:10.1684/ecn.2018.0404

Sara Harsini, Amene Saghazadeh, Saharnaz Nedjat, Nima Rezaei

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引用次数: 6

摘要

背景:包括白细胞介素-10 (IL-10)在内的细胞因子基因在幼年特发性关节炎(JIA)的发病机制中起重要作用。本研究旨在确定IL-10多态性是否与JIA易感性有关。方法:对IL-10 -1082 G/A、-592 C/A和-819 C/T多态性与JIA之间的关系进行meta分析。荟萃分析共纳入7项研究，涉及1785名患者和6142名对照。结果:IL-10 -592 C/A和-819 C/T多态性的荟萃分析显示，在研究参与者、高加索或中东参与者中，与JIA没有关联。所有研究参与者(高加索人和中东人)的IL-10 -1082等位基因荟萃分析显示与RA有显著相关性(总体or分别为1.17、1.15和1.41)。对IL-10 -1082 G/A多态性的AA与GG基因型的meta分析显示，在中东国家的参与者中，JIA与AA基因型有显著相关性(OR = 3.66, 95% CI = 1.44-9.29, P = 0.006)。此外，对IL-10 -1082 G/A多态性的GG与AA+GA基因型的meta分析显示，GG基因型是中东亚组JIA的保护因素(OR = 0.44, 95% CI = 0.20-0.94, P = 0,04)。此外，4项Hardy-Weinberg平衡研究中IL-10 -1082 A等位基因的meta分析显示，JIA与JIA有显著相关性(OR = 1.17, 95% CI = 1.07-1.28, P = 0.0009)。IL-10 (-1082， -819， -592) ACC、ATA和GCC单倍型与JIA无相关性。结论:这些结果提示IL-10 -1082 G/A多态性与JIA易感性有关。

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Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis.

Background: Cytokine genes, including interleukin-10 (IL-10), are known to play important roles in the pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms confer susceptibility to JIA.

Methods: A meta-analysis was performed on the associations between the IL-10 -1082 G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies involving 1,785 patients and 6,142 controls were considered in the meta-analysis.

Results: Meta-analysis of the IL-10 -592 C/A and -819 C/T polymorphisms showed no association with JIA in the study participants, or in Caucasian or Middle Eastern participants. Meta-analysis of the IL-10 -1082 A allele in all study participants, Caucasian and Middle Eastern, showed significant associations with RA (overall ORs were 1.17, 1.15, and 1.41, respectively). Meta-analysis of the AA versus GG genotype of the IL-10 -1082 G/A polymorphism revealed significant associations with JIA (OR = 3.66, 95% CI = 1.44-9.29, P = 0.006) in participants from Middle Eastern countries. Additionally, meta-analysis of the GG versus AA+GA genotypes of the IL-10 -1082 G/A polymorphism revealed the GG genotype as the protective factor against JIA in the Middle Eastern subgroup (OR = 0.44, 95% CI = 0.20-0.94, P = 0,04). Moreover, meta-analysis of the IL-10 -1082 A allele in 4 studies on Hardy-Weinberg equilibrium showed a significant association with JIA (OR = 1.17, 95% CI = 1.07-1.28, P = 0.0009). No association was found between the IL-10 (-1082, -819, -592) ACC, ATA, and GCC haplotypes and JIA.

Conclusions: These results suggest that the IL-10 -1082 G/A polymorphism confers susceptibility to JIA.

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来源期刊

European cytokine network 生物-免疫学

CiteScore

5.70

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The journal that brings together all areas of work involving cytokines. European Cytokine Network is an electronic journal that publishes original articles and abstracts every quarter to provide an essential bridge between researchers and clinicians with an interest in this cutting-edge field. The journal has become a must-read for specialists in the field thanks to its swift publication and international circulation. The journal is referenced in several databases, including Medline, which is testament to its scientific quality.