80岁患者原发性中枢神经系统淋巴瘤逆转录病毒感染的持久完全缓解。

Q4 Medicine

Connecticut Medicine Pub Date : 2017-04-01

Michael Del Rosario, Henry Tsai, Constantin A Dasanu

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引用次数: 0

摘要

老年人类免疫缺陷病毒(HIV)感染者对其提供者提出了一系列独特的挑战。心血管、代谢、神经退行性和肾脏疾病以及某些癌症在这一队列中更为常见，这是由于炎症率升高。尽管生存率仍然受到影响，但有效的抗逆转录病毒药物和高剂量甲氨蝶呤(HD-MTX)的整合被证明可以改善原发性中枢神经系统淋巴瘤(PCNSL)的hiv感染患者的临床结果。然而，老年人PCNSL的最佳管理尚不清楚。我们报告了一位80岁的hiv相关PCNSL患者，他通过HD-MTX和美罗华单抗获得了持久的完全缓解。在确诊18个月后，他的病情完全缓解。我们的病例支持在非常老的hiv相关PCNSL患者中使用HD-MTX/rituximab联合治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Durable Complete Response of Primary CNS Lymphoma in an 80-Year-Old Patient with Retroviral Infection.

People aging with human immunodeficiencyvirus (HIV) present a unique set of challenges for their providers. Cardiovascular, metabolic, neurodegenerative, and renal disorders, and certain cancers are more common in this cohort, which is attributed to elevated rates of inflammation. Although survival remains compromised, integration of efficacious antiretrovirals and high-dose methotrexate (HD-MTX) was shown to improve clinical results in HIV-infected patients with primary central nervous system lymphoma (PCNSL). However, optimal management of PCNSL in the elderly is not known. We present the case of an 80-year-old patientwith HIV-associated PCNSL who achieved a durable complete response with HD-MTX andrituximab. He remains in complete remission 18 months after the diagnosis. Our case supports using the HD-MTX/rituximab combination in the very old subjects with HIV-related PCNSL.

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来源期刊

Connecticut Medicine Medicine-Medicine (all)

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期刊介绍： The Connecticut State Medical Society (CSMS) is a federation of eight component county medical associations, with a total membership exceeding 7,000 physicians. CSMS itself is a constituent state entity of the American Medical Association. Founded by the physician-patriots of the American Revolution, the Society operates from a heritage of democratic principles embodied in its Charter and Bylaws. The base of all authority in CSMS is, of course, the individual physician member. It is the decisions of members in their own county associations that ultimately determine the nature of the Society"s policies and activities.