大环药物发现的最新趋势及超越ro5。

Q1 Pharmacology, Toxicology and Pharmaceutics

Progress in medicinal chemistry Pub Date : 2018-01-01 Epub Date: 2018-03-22 DOI:10.1016/bs.pmch.2018.01.002

Sulejman Alihodžić, Mirjana Bukvić, Ivaylo J Elenkov, Antun Hutinec, Sanja Koštrun, Dijana Pešić, Gordon Saxty, Linda Tomašković, Dinko Žiher

{"title":"大环药物发现的最新趋势及超越ro5。","authors":"Sulejman Alihodžić, Mirjana Bukvić, Ivaylo J Elenkov, Antun Hutinec, Sanja Koštrun, Dijana Pešić, Gordon Saxty, Linda Tomašković, Dinko Žiher","doi":"10.1016/bs.pmch.2018.01.002","DOIUrl":null,"url":null,"abstract":"This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in the field assessed. The physicochemical properties, which have provided both successes and challenges, especially in scale-up, are discussed. A recent patent literature is reviewed and the chapter concludes with a perspective on the future of macrocyclic drug discovery.","PeriodicalId":20755,"journal":{"name":"Progress in medicinal chemistry","volume":"57 1","pages":"113-233"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.pmch.2018.01.002","citationCount":"13","resultStr":"{\"title\":\"Current Trends in Macrocyclic Drug Discovery and beyond-Ro5.\",\"authors\":\"Sulejman Alihodžić, Mirjana Bukvić, Ivaylo J Elenkov, Antun Hutinec, Sanja Koštrun, Dijana Pešić, Gordon Saxty, Linda Tomašković, Dinko Žiher\",\"doi\":\"10.1016/bs.pmch.2018.01.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in the field assessed. The physicochemical properties, which have provided both successes and challenges, especially in scale-up, are discussed. A recent patent literature is reviewed and the chapter concludes with a perspective on the future of macrocyclic drug discovery.\",\"PeriodicalId\":20755,\"journal\":{\"name\":\"Progress in medicinal chemistry\",\"volume\":\"57 1\",\"pages\":\"113-233\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/bs.pmch.2018.01.002\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in medicinal chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.pmch.2018.01.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/3/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/bs.pmch.2018.01.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/3/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 13

摘要

本章将讨论最近关于超越五法则(bRo5)的大周期和类药物性质空间的文献。讨论了属于这一定义的化学类别的趋势，并评估了该领域最新技术的影响。讨论了其物理化学性质，这些性质提供了成功和挑战，特别是在扩大规模方面。回顾了最近的专利文献，并对大环药物发现的未来进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Current Trends in Macrocyclic Drug Discovery and beyond-Ro5.

This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in the field assessed. The physicochemical properties, which have provided both successes and challenges, especially in scale-up, are discussed. A recent patent literature is reviewed and the chapter concludes with a perspective on the future of macrocyclic drug discovery.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Progress in medicinal chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

15.60

自引率

0.00%

发文量

期刊介绍： This series has a long established reputation for excellent coverage of almost every facet of Medicinal Chemistry and is one of the most respected and instructive sources of information on the subject. The latest volume certifies to the continuing success of a unique series reflecting current progress in a broadly developing field of science.