Philippe Jeandet , Md. Sahab Uddin , Christophe Clément , Aziz Aziz , Cédric Jacquard , Haroon Khan , Muhammad Ajmal Shah , Essaid Ait Barka , Mattheos Koffas , Seyed Mohammad Nabavi , Eduardo Sobarzo-Sánchez , Jean-Hugues Renault
{"title":"生产用于研究其生物活性的高分子有序二苯乙烯低聚物：全合成、生物催化合成和植物系统生产†","authors":"Philippe Jeandet , Md. Sahab Uddin , Christophe Clément , Aziz Aziz , Cédric Jacquard , Haroon Khan , Muhammad Ajmal Shah , Essaid Ait Barka , Mattheos Koffas , Seyed Mohammad Nabavi , Eduardo Sobarzo-Sánchez , Jean-Hugues Renault","doi":"10.1039/d2np00073c","DOIUrl":null,"url":null,"abstract":"<div><p>Though the iconic stilbene resveratrol and its related dimers constitute a top storyline in the field of natural product research, resveratrol oligomers (condensation >2) have been left aside despite their higher biological activity compared to that of the monomers. This situation largely results from the difficulty of getting them in sufficient quantities to enable evaluation of their biological properties <em>in vivo</em>. We present here a synthetic and critical analysis of the methods used for the production of high molecular-ordered stilbene oligomers of potential biomedical interest, gathering the most salient data regarding the approaches employed to prepare them by total synthesis, use of biomimetic approaches or through plant systems.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"40 5","pages":"Pages 1045-1057"},"PeriodicalIF":10.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems†\",\"authors\":\"Philippe Jeandet , Md. Sahab Uddin , Christophe Clément , Aziz Aziz , Cédric Jacquard , Haroon Khan , Muhammad Ajmal Shah , Essaid Ait Barka , Mattheos Koffas , Seyed Mohammad Nabavi , Eduardo Sobarzo-Sánchez , Jean-Hugues Renault\",\"doi\":\"10.1039/d2np00073c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Though the iconic stilbene resveratrol and its related dimers constitute a top storyline in the field of natural product research, resveratrol oligomers (condensation >2) have been left aside despite their higher biological activity compared to that of the monomers. This situation largely results from the difficulty of getting them in sufficient quantities to enable evaluation of their biological properties <em>in vivo</em>. We present here a synthetic and critical analysis of the methods used for the production of high molecular-ordered stilbene oligomers of potential biomedical interest, gathering the most salient data regarding the approaches employed to prepare them by total synthesis, use of biomimetic approaches or through plant systems.</p></div>\",\"PeriodicalId\":94,\"journal\":{\"name\":\"Natural Product Reports\",\"volume\":\"40 5\",\"pages\":\"Pages 1045-1057\"},\"PeriodicalIF\":10.2000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Reports\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S0265056823000818\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0265056823000818","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems†
Though the iconic stilbene resveratrol and its related dimers constitute a top storyline in the field of natural product research, resveratrol oligomers (condensation >2) have been left aside despite their higher biological activity compared to that of the monomers. This situation largely results from the difficulty of getting them in sufficient quantities to enable evaluation of their biological properties in vivo. We present here a synthetic and critical analysis of the methods used for the production of high molecular-ordered stilbene oligomers of potential biomedical interest, gathering the most salient data regarding the approaches employed to prepare them by total synthesis, use of biomimetic approaches or through plant systems.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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