I G Litovka, V Ya Berezovskyi, S P Veselskyi, U O Zhernoklov
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BONE TISSUE REMODELING AFTER THE INTRODUCTION OF EXOGENOUS MELATONIN IN DIFFERENT SEASONS.
We studied the impact of pharmacological doses (5 mg / kg) of
melatonin on the parameters of bone remodeling in 3 month-old
male Wistar rats in autumn and spring. In autumn experiments,
introduction of melatonin to young rats caused an increase of
alkaline phosphatase by 43,9% and hialuronidase activity by
15,4% and decreased the content of glycosaminoglycans by
46,7%. The concentration of total lipids and triglycerides was
decreased. In spring, the introduction of melatonin to young
rats inhibited the physiological remodeling of bone tissue,
reduced the activity of alkaline phosphatase and increased
the activity of acid on the 78% and tartrate resistant acid
phosphatases by 72% regardless of the oxygen consumption
level. The concentration of glycosaminoglycans and free amino
acids increased. Such changes may disturb the integrity of the
organic matrix and reduce the fixation of inorganic component
of connective tissue – hydroxyapatite crystals.
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