百里醌的保肝作用综述。

Q1 Agricultural and Biological Sciences
Mohammad-Foad Noorbakhsh, Farzad Hayati, Saeed Samarghandian, Hanieh Shaterzadeh-Yazdi, Tahereh Farkhondeh
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引用次数: 27

摘要

背景:肝脏疾病是全球公认的主要医学问题。几种草药已被研究用于肝脏相关疾病的治疗。目的:在此背景下,百里醌(TQ)作为黑草的主要成分,近年来一直被关注于肝脏疾病的治疗。据报道,TQ具有抑制肝脏疾病的降血脂作用,可以阻止脂肪酸在肝细胞中的积累。TQ的另一种活性,不仅在慢性肝病的治疗中,而且在致癌方面,是其强大的抗氧化作用,它影响几种信号通路。结果:TQ对NF-κβ的影响是黄酮类化合物的保肝作用。近年来,开发了一些具有保护作用的TQ衍生物专利。本文还讨论了我们的研究结果与该药物的专利。结论:本综述的目的是,虽然实验研究表明了TQ对肝脏疾病的有益作用,但需要更多设计的人体临床试验来证实TQ的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Overview of Hepatoprotective Effects of Thymoquinone.

Background: Liver diseases are globally recognized as major medical problems. Several species of herbal medicine have been investigated for the management of liver-related diseases.

Objective: In this context, Thymoquinone (TQ) as the main constituent of Nigella sativa has long been focused for the treatment of liver diseases in recent years. To suppressing liver diseases, it was reported that TQ exhibits hypolipidic effects, which prevented the fatty acid accumulation in the hepatocytes. The other activity of TQ, not only in the management of chronic liver diseases but also regarding the carcinogenesis, is its potent antioxidant effects, which affect several signaling pathways.

Result: The effect of TQ on NF-κβ is the hepatoprotective effect of this flavonoid. Recently, a few patents of TQ derivatives for protective effects have been developed. This article also discusses our findings with the patents for this agent.

Conclusion: The present review purposed that although the experimental studies indicated the beneficial effects of TQ against liver diseases, more designed clinical trials in human are needed to confirm the safety and efficacy of TQ.

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来源期刊
Recent patents on food, nutrition & agriculture
Recent patents on food, nutrition & agriculture Agricultural and Biological Sciences-Agronomy and Crop Science
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