肿瘤影像引导手术:降低手术切缘阳性发生率的策略。

IF 7.9 Q1 Medicine
Kathryn R Tringale, John Pang, Quyen T Nguyen
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引用次数: 48

摘要

许多实体癌的主要治疗包括手术切除或放射治疗,有或没有使用辅助治疗。这可以包括在初次手术治疗后增加放疗和化疗,或在初次放疗后增加化疗和挽救性手术。无论是手术还是放射治疗,都需要精确的肿瘤解剖定位。如果肿瘤在最初的治疗中没有得到充分的靶向,疾病可能会复发,如果靶向范围太广,可能会对附近的结构或剩余的正常组织造成不必要的发病率。术中使用造影剂的荧光成像是一个快速发展的领域,用于提高肿瘤手术的可视化,以便于切除以获得阴性边缘。基于针对肿瘤中优先表达的受体的表面标记或配体的抗体,有多种肿瘤可视化策略。在这篇文章中,我们回顾了一些最常见的实体瘤的手术切缘阳性的发生率和临床意义。在此背景下,我们提出了正在进行的临床和临床前研究,重点是使用术中造影剂来改善手术边缘。本文分类如下:实验室方法与技术>成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Image-guided surgery in cancer: A strategy to reduce incidence of positive surgical margins.

Primary treatment for many solid cancers includes surgical excision or radiation therapy, with or without the use of adjuvant therapy. This can include the addition of radiation and chemotherapy after primary surgical therapy, or the addition of chemotherapy and salvage surgery to primary radiation therapy. Both primary therapies, surgery and radiation, require precise anatomic localization of tumor. If tumor is not targeted adequately with initial treatment, disease recurrence may ensue, and if targeting is too broad, unnecessary morbidity may occur to nearby structures or remaining normal tissue. Fluorescence imaging using intraoperative contrast agents is a rapidly growing field for improving visualization in cancer surgery to facilitate resection in order to obtain negative margins. There are multiple strategies for tumor visualization based on antibodies against surface markers or ligands for receptors preferentially expressed in cancer. In this article, we review the incidence and clinical implications of positive surgical margins for some of the most common solid tumors. Within this context, we present the ongoing clinical and preclinical studies focused on the use of intraoperative contrast agents to improve surgical margins. This article is categorized under: Laboratory Methods and Technologies > Imaging.

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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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