{"title":"诱导型胆固醇外排肽:FAMP提高心肌梗死后生存率","authors":"Eiji Yahiro , Yoshinari Uehara , Emi Kawachi , Setsuko Ando , Shin-ichiro Miura , Keijiro Saku","doi":"10.1016/j.ijchv.2014.05.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI).</p></div><div><h3>Method and results</h3><p>Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased.</p></div><div><h3>Conclusion</h3><p>This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.</p></div>","PeriodicalId":90542,"journal":{"name":"International journal of cardiology. Heart & vessels","volume":"4 ","pages":"Pages 135-137"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchv.2014.05.005","citationCount":"4","resultStr":"{\"title\":\"Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP\",\"authors\":\"Eiji Yahiro , Yoshinari Uehara , Emi Kawachi , Setsuko Ando , Shin-ichiro Miura , Keijiro Saku\",\"doi\":\"10.1016/j.ijchv.2014.05.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI).</p></div><div><h3>Method and results</h3><p>Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased.</p></div><div><h3>Conclusion</h3><p>This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.</p></div>\",\"PeriodicalId\":90542,\"journal\":{\"name\":\"International journal of cardiology. Heart & vessels\",\"volume\":\"4 \",\"pages\":\"Pages 135-137\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ijchv.2014.05.005\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of cardiology. Heart & vessels\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214763214000388\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of cardiology. Heart & vessels","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214763214000388","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP
Background
There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI).
Method and results
Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased.
Conclusion
This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
