[从根本上说，分子遗传癌症研究的可重复性很低]。

Genetika Pub Date : 2016-07-01

I V Alekseenko, V V Pleshkan, G S Monastyrskaya, A I Kuzmich, E V Snezhkov, D A Didych, E D Sverdlov

{"title":"[从根本上说，分子遗传癌症研究的可重复性很低]。","authors":"I V Alekseenko, V V Pleshkan, G S Monastyrskaya, A I Kuzmich, E V Snezhkov, D A Didych, E D Sverdlov","doi":"","DOIUrl":null,"url":null,"abstract":"The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.","PeriodicalId":12707,"journal":{"name":"Genetika","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Fundamentally low reproducibility in molecular genetic cancer research].\",\"authors\":\"I V Alekseenko, V V Pleshkan, G S Monastyrskaya, A I Kuzmich, E V Snezhkov, D A Didych, E D Sverdlov\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.\",\"PeriodicalId\":12707,\"journal\":{\"name\":\"Genetika\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genetika\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetika","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

这篇综述讨论了癌症治疗中多次失败的原因，这可能主要是由于癌症基因组的过度变异性。它们能够在肿瘤发展过程中改变它们的空间和时间结构。提出了生物医学数据不可重复性的主要原因，以及针对最稳定的肿瘤特征改进治疗效果的可能手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Fundamentally low reproducibility in molecular genetic cancer research].

The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Genetika

自引率

0.00%

发文量