l -精氨酸琥珀酸钠——用于治疗和预防阿霉素引起的心脏毒性的新型血管舒张药物。

V V Valeev, A P Trashkov, A L Kovaleko, A U Petrov, A G Vasiliev
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引用次数: 0

摘要

目的:探讨l -精氨酸琥珀酸钠对阿霉素致大鼠心肌损伤的保护作用。方法。通过反映心肌过氧化强度和结构功能变化的形态计量学和生化变化来评估药物的有效性。结果。用于治疗和预防四环型心肌病的l -精氨酸琥珀酸钠被证明可以降低阿霉素的作用,减轻心肌细胞的破坏和心肌肥厚引起的左心室功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity.

The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.

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