系统性青少年特发性关节炎的治疗及IL-1和IL-6抑制作用的最新进展。

IF 1.7 Q2 PEDIATRICS

Adolescent Health Medicine and Therapeutics Pub Date : 2017-11-09 eCollection Date: 2017-01-01 DOI:10.2147/AHMT.S109495

Sriharsha Grevich, Susan Shenoi

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引用次数: 45

摘要

系统性青少年特发性关节炎(SJIA)是一种以关节炎和全身炎症为特征的疾病，包括发烧、皮疹、肝脾肿大、淋巴结病和浆液炎。表现可以是可变的，关节炎可能是后来的特征。巨噬细胞激活综合征可能是一种危及生命的并发症，需要早期识别和及时治疗。对SJIA生物学的深入了解导致了细胞因子靶向治疗的发展，主要是白细胞介素-1 (IL-1)和IL-6抑制剂，它们显著改善了预后。在这篇综述中，我们提供了对SJIA生物学认识的最新进展以及治疗选择。

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Update on the management of systemic juvenile idiopathic arthritis and role of IL-1 and IL-6 inhibition.

Systemic juvenile idiopathic arthritis (SJIA) is a disease marked with arthritis and several features of systemic inflammation including fevers, rashes, hepatosplenomegaly, lymphadenopathy, and serositis. The presentation can be variable and arthritis can be a later feature. Macrophage activation syndrome can be a life-threatening complication of this illness and requires early recognition and prompt therapy. Advancements in understanding the biology of SJIA have led to the development of cytokine-targeted therapies, mainly interleukin-1 (IL-1) and IL-6 inhibitors that have significantly improved outcomes. In this review, we provide an update on the advances in the understanding of SJIA biology and also the therapeutic options.

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来源期刊

Adolescent Health Medicine and Therapeutics PEDIATRICS-

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Adolescent Health, Medicine and Therapeutics is an international, peer reviewed, open access journal focusing on health, pathology, and treatment issues specific to the adolescent age group, including health issues affecting young people with cancer. Original research, reports, editorials, reviews, commentaries and adolescent-focused clinical trial design are welcomed. All aspects of health maintenance, preventative measures, disease treatment interventions, studies investigating the poor outcomes for some treatments in this group of patients, and the challenges when transitioning from adolescent to adult care are addressed within the journal. Practitioners from all disciplines are invited to submit their work as well as health care researchers and patient support groups. Areas covered include: Physical and mental development in the adolescent period, Behavioral issues, Pathologies and treatment interventions specific to this age group, Prevalence and incidence studies, Diet and nutrition, Specific drug handling, efficacy, and safety issues, Drug development programs, Outcome studies, patient satisfaction, compliance, and adherence, Patient and health education programs and studies.