凋亡蛋白Bcl-2家族调控应激诱导的细胞死亡。

Q3 Biochemistry, Genetics and Molecular Biology

Molecular Membrane Biology Pub Date : 2016-09-01 Epub Date: 2017-11-23 DOI:10.1080/09687688.2017.1400600

Rabih Roufayel

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引用次数: 25

摘要

在许多人类疾病中，细胞凋亡通常是不受控制的。热诱导细胞凋亡是研究蛋白质错误折叠后果的一个模型系统，由Bcl-2蛋白家族介导。这个家族包括促凋亡和抗凋亡成员，控制线粒体完整性。仅bh3的促凋亡成员是凋亡细胞死亡的强诱导剂。蛋白质损伤应激可以激活一个被称为凋亡的细胞破坏过程。促凋亡的BH3-only蛋白和转录因子通过抑制抗凋亡的Bcl-2家族蛋白在短时间内消灭癌细胞来激活这一死亡途径。

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Regulation of stressed-induced cell death by the Bcl-2 family of apoptotic proteins.

Apoptosis is often deregulated in a number of human diseases. Heat-induced apoptosis is a model system for studying the consequences of protein misfolding and is mediated by the Bcl-2 family of proteins. This family consists of both pro-apoptotic and anti-apoptotic members that control mitochondrial integrity. The BH3-only pro-apoptotic members are strong inducers of apoptotic cell death. Protein damaging stress can activate a process of cellular destruction known as apoptosis. The pro-apoptotic BH3-only proteins and transcription factors activate this death pathway by inhibiting the anti-apoptotic Bcl-2 family proteins eliminating cancer cells in a short period of time.

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来源期刊

Molecular Membrane Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation. Molecular Membrane Biology provides a forum for high quality research that serves to advance knowledge in molecular aspects of biological membrane structure and function. The journal welcomes submissions of original research papers and reviews in the following areas: • Membrane receptors and signalling • Membrane transporters, pores and channels • Synthesis and structure of membrane proteins • Membrane translocation and targeting • Lipid organisation and asymmetry • Model membranes • Membrane trafficking • Cytoskeletal and extracellular membrane interactions • Cell adhesion and intercellular interactions • Molecular dynamics and molecular modelling of membranes. • Antimicrobial peptides.