{"title":"肾毒性药物。","authors":"B Popović, I Šutić, N Bašić Marković","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Renal tissue is sensitive to the effect of potentially nephrotoxic drugs and other substances that are available over-the-counter\nor can be purchased at healthy food stores or elsewhere, and harmful substances from the environment. The\nharmful effects of these substances lead to the development of recognizable clinical syndromes, including acute or chronic\nrenal failure, tubulopathy, and proteinuria. Risk factors that influence the development of kidney disease induced by drugs\nare divided into those related to patient characteristics, drug characteristics, and renal function. Drugs that commonly\nexhibit nephrotoxic effects are analgesics, antimicrobials, chemotherapeutics, contrast agents, immunosuppressants,\nherbal preparations and substances containing heavy metals. Family physician must carefully observe their patients,\nnurturing individual approach to drug selection and determining the dose. Renal function can quickly return to normal if the\ndamage is recognized on time. Recent research yields insights into the identification of new biomarkers that will contribute\nto early detection of drug induced kidney damage.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[NEPHROTOXIC DRUGS].\",\"authors\":\"B Popović, I Šutić, N Bašić Marković\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Renal tissue is sensitive to the effect of potentially nephrotoxic drugs and other substances that are available over-the-counter\\nor can be purchased at healthy food stores or elsewhere, and harmful substances from the environment. The\\nharmful effects of these substances lead to the development of recognizable clinical syndromes, including acute or chronic\\nrenal failure, tubulopathy, and proteinuria. Risk factors that influence the development of kidney disease induced by drugs\\nare divided into those related to patient characteristics, drug characteristics, and renal function. Drugs that commonly\\nexhibit nephrotoxic effects are analgesics, antimicrobials, chemotherapeutics, contrast agents, immunosuppressants,\\nherbal preparations and substances containing heavy metals. Family physician must carefully observe their patients,\\nnurturing individual approach to drug selection and determining the dose. Renal function can quickly return to normal if the\\ndamage is recognized on time. Recent research yields insights into the identification of new biomarkers that will contribute\\nto early detection of drug induced kidney damage.</p>\",\"PeriodicalId\":35756,\"journal\":{\"name\":\"Acta Medica Croatica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Medica Croatica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Medica Croatica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Renal tissue is sensitive to the effect of potentially nephrotoxic drugs and other substances that are available over-the-counter
or can be purchased at healthy food stores or elsewhere, and harmful substances from the environment. The
harmful effects of these substances lead to the development of recognizable clinical syndromes, including acute or chronic
renal failure, tubulopathy, and proteinuria. Risk factors that influence the development of kidney disease induced by drugs
are divided into those related to patient characteristics, drug characteristics, and renal function. Drugs that commonly
exhibit nephrotoxic effects are analgesics, antimicrobials, chemotherapeutics, contrast agents, immunosuppressants,
herbal preparations and substances containing heavy metals. Family physician must carefully observe their patients,
nurturing individual approach to drug selection and determining the dose. Renal function can quickly return to normal if the
damage is recognized on time. Recent research yields insights into the identification of new biomarkers that will contribute
to early detection of drug induced kidney damage.
期刊介绍:
ACTA MEDICA CROATICA publishes original contributions to medical sciences, that have not been previously published. All manuscripts should be written in English.