基因-基因相互作用分析

Current Protocols in Human Genetics Pub Date : 2018-02-13 DOI:10.1002/cphg.45

Brian S. Cole, Molly A. Hall, Ryan J. Urbanowicz, Diane Gilbert-Diamond, Jason H. Moore

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引用次数: 29

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Analysis of Gene-Gene Interactions

The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research. © 2017 by John Wiley & Sons, Inc.

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Current Protocols in Human Genetics Biochemistry, Genetics and Molecular Biology-Genetics

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期刊介绍： Current Protocols in Human Genetics is the resource for designing and running successful research projects in all branches of human genetics.